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Common-lymphoid-progenitor-independent pathways of innate and T lymphocyte development

Posted April 19, 2016 | Publications

Ghaedi M, Steer CA, Martinez-Gonzalez I, Halim TYF, Abraham N & Takei F. Common-lymphoid-progenitor-independent pathways of innate and T lymphocyte development.  Cell Reports 15: 471-480, 2016.

Abstract:

All lymphocytes are thought to develop from common lymphoid progenitors (CLPs). However, lymphoid- primed multipotent progenitors (LMPPs) are more efficient than CLPs in differentiating into T cells and group 2 innate lymphoid cells (ILC2s). Here, we have divided LMPPs into CD127 (LMPP-s) and CD127+ (LMPP+s) subsets and compared them with Ly6D and Ly6D+ CLPs. Adult LMPP+s differentiated into T cells and ILCs more rapidly and efficiently than other progenitors in transplantation assays. The development of T cells and ILC2s is highly active in the neonatal period. Neonatal CLPs are rare and, unlike prominent neonatal LMPP+s, do not efficiently differentiate into T cells and ILC2s. ILC2s generated in the neonatal period are long lived and persist in adult tissues. These results suggest that some ILCs and T cells may develop from LMPP+s via CLP-independent pathways.

PMID: 27068476