BC Cancer Center for Genetic Modeling

Danny Chui Genetic Modeling Core Leader Email: dchui@bccrc.ca BC Cancer Research Center 675 West 10th Avenue Vancouver, BC Tel: 604-675-8000 ext 7733 Fax: 604-877-0712

 

 

The BC Cancer Center for Genetic Modeling (CGM) was initiated in 2004 as an expansion of the Terry Fox Labs transgenic core after a decade of successful operations.  It is situated within the new BC Cancer Research Center (BCCRC) building that houses a 1,995 m² rodent facility (ARC) that provides a barrier environment that matches the highest standards of pathogen control of commercial facilities around the world.  A Level III biohazard facility, an Embryonic Stem (ES) cell lab, and mouse phenotyping suites also exist as infrastructure support for the CGM.

The CGM have state of the art capabilities for generating mouse mutant models through ES cell gene targeting and pronuclear microinjection of mouse zygotes.  In addition the CGM provide services for cryo-preservation and mouse re-derivation, and has an ES core that can derive and manipulate various strains of ES cells.  The CGM also has a mandate to develop or bring in new platform technologies to make the generation of mouse mutants quicker and easier as well as to develop technologies to further facilitate mouse embryo manipulations. To this end, the CGM has successfully established new technologies including lentiviral transgenics and in vitro fertilization (IVF).    

The CGM can provide the following fee for services:  Pronuclear injections into mouse zygotes, blastocyst injections with any strain of ES cells, tetraploid blastocyst generation and injection, gene targeting into ES cells, ES cell derivation, cre mediated recombination, mouse strain rederivation, IVF, cryopreservation of mouse strains, and lentiviral transgenics.

Lab Personnel:

Nicole Hofs