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Dr. Arefeh Rouhi — PhD

Staff Scientist

Overview
Publications

Wolf C, Garding A, Filarsky K, Bahlo J, Robrecht S, Becker N, Zucknick M, Rouhi A, Weigel A, Claus R, Weichenhan D, Eichhorst B, Fischer K, Hallek M, Kuchenbauer F, Plass C, Dohner H, Stilgenbauer S, Lichter P & Mertens D. NFATC1 activation by DNA hypomethylation in chronic lymphocytic leukemia correlates with clinical staging and can be inhibited by ibrutinib. Int J Cancer 142:322-333, 2018. View Abstract

Schneider E, Staffas A, Rohner L, Malmberg ED, Ashouri A, Krowiorz K, Pochert N, Miller C, Wei SY, Arabanian L, Buske C, Dohner H, Bullinger L, Fogelstrand L, Heuser M, Dohner K, Xiang P, Ruschmann J, Petriv OI, Heravi-Moussavi A, Hansen CL, Hirst M, Humphries RK, Rouhi A, Palmqvist L & Kuchenbauer F. Micro-ribonucleic acid-155 is a direct target of Meis1, but not a driver in acute myeloid leukemia. Haematologica 103:246-255, 2018. View Abstract

Martins LR, Bung RK, Koch S, Richter K, Schwarzmuller L, Terhardt D, Kurtulmus B, Niehrs C, Rouhi A, Lohmann I, Pereira G, Frohling S, Glimm H & Scholl C. Stk33 is required for spermatid differentiation and male fertility in mice. Dev Biol 433:84-93, 2018. View Abstract

Grasedieck S, Mulaw M, Sperb N, Wessinger K, Rouhi A, Bommer M, Bromberg JEC, Otto M, Tumani H, von Arnim CAF, Mertens D & Kuchenbauer F. Comprehensive microRNA expression profiling in cerebrospinal fluid distinguishes between neurological disease classes. Neuropathol Appl Neurobiol 2018. View Abstract

Bhayadia R, Krowiorz K, Haetscher N, Jammal R, Emmrich S, Obulkasim A, Fiedler J, Schwarzer A, Rouhi A, Heuser M, Wingert S, Bothur S, Dohner K, Matzig T, Ng M, Reinhardt D, Dohner H, Zwaan CM, van den Heuvel Eibrink M, Heckl D, Fornerod M, Thum T, Humphries RK, Rieger MA, Kuchenbauer F & Klusmann JH. Endogenous Tumor Suppressor microRNA-193b: Therapeutic and Prognostic Value in Acute Myeloid Leukemia. J Clin Oncol 36:1007-1016, 2018. View Abstract

Rouhi A, Miller C, Grasedieck S, Reinhart S, Stolze B, Dohner H, Kuchenbauer F, Bullinger L, Frohling S & Scholl C. Prospective identification of resistance mechanisms to HSP90 inhibition in KRAS mutant cancer cells. Oncotarget 8:7678-7690, 2017. View Abstract

Rouhi A & Kuchenbauer F. FOXtrotting with PUMILIOs. Blood 129:2459-2460, 2017. View Abstract

Mohr S, Doebele C, Comoglio F, Berg T, Beck J, Bohnenberger H, Alexe G, Corso J, Strobel P, Wachter A, Beissbarth T, Schnutgen F, Cremer A, Haetscher N, Gollner S, Rouhi A, Palmqvist L, Rieger MA, Schroeder T, Bonig H, Muller-Tidow C, Kuchenbauer F, Schutz E, Green AR, Urlaub H, Stegmaier K, Humphries RK, Serve H & Oellerich T. Hoxa9 and Meis1 Cooperatively Induce Addiction to Syk Signaling by Suppressing miR-146a in Acute Myeloid Leukemia. Cancer Cell 31:549-562 e511, 2017. View Abstract

Liu Y, Steinestel K, Rouhi A, Armacki M, Diepold K, Chiosis G, Simmet T, Seufferlein T & Azoitei N. STK33 participates to HSP90-supported angiogenic program in hypoxic tumors by regulating HIF-1alpha/VEGF signaling pathway. Oncotarget 8:77474-77488, 2017. View Abstract

Itkin T, Kumari A, Schneider E, Gur-Cohen S, Ludwig C, Brooks R, Kollet O, Golan K, Khatib-Massalha E, Russo CM, Chisholm JD, Rouhi A, Geiger H, Hornstein E, Kerr WG, Kuchenbauer F & Lapidot T. MicroRNA-155 promotes G-CSF-induced mobilization of murine hematopoietic stem and progenitor cells via propagation of CXCL12 signaling. Leukemia 31:1247-1250, 2017. View Abstract

Hirsch S, Blatte TJ, Grasedieck S, Cocciardi S, Rouhi A, Jongen-Lavrencic M, Paschka P, Kronke J, Gaidzik VI, Dohner H, Schlenk RF, Kuchenbauer F, Dohner K, Dolnik A & Bullinger L. Circular RNAs of the nucleophosmin (NPM1) gene in acute myeloid leukemia. Haematologica 102:2039-2047, 2017. View Abstract

Bohl SR, Kuchenbauer F, von Harsdorf S, Kloevekorn N, Schonsteiner SS, Rouhi A, Schwarzwalder P, Dohner H, Bunjes D & Bommer M. Thrombotic Microangiopathy after Allogeneic Stem Cell Transplantation: A Comparison of Eculizumab Therapy and Conventional Therapy. Biol Blood Marrow Transplant 23:2172-2177, 2017. View Abstract

Schneider E, Staffas A, Rohner L, Krowiorz K, Heuser M, Dohner K, Bullinger L, Dohner H, Fogelstrand L, Rouhi A, Kuchenbauer F & Palmqvist L. MicroRNA-155 is upregulated in MLL-rearranged AML but its absence does not affect leukemia development. Exp Hematol 44:1166-1171, 2016. View Abstract

Krowiorz K, Ruschmann J, Lai C, Ngom M, Maetzig T, Martins V, Scheffold A, Schneider E, Pochert N, Miller C, Palmqvist L, Staffas A, Mulaw M, Bohl SR, Buske C, Heuser M, Kraus J, O'Neill K, Hansen CL, Petriv OI, Kestler H, Dohner H, Bullinger L, Dohner K, Humphries RK, Rouhi A & Kuchenbauer F. MiR-139-5p is a potent tumor suppressor in adult acute myeloid leukemia. Blood Cancer J 6:e508, 2016. View Abstract

Azoitei N, Becher A, Steinestel K, Rouhi A, Diepold K, Genze F, Simmet T & Seufferlein T. PKM2 promotes tumor angiogenesis by regulating HIF-1alpha through NF-kappaB activation. Mol Cancer 15:3, 2016. View Abstract

Gentner B, Pochert N, Rouhi A, Boccalatte F, Plati T, Berg T, Sun SM, Mah SM, Mirkovic-Hosle M, Ruschmann J, Muranyi A, Leierseder S, Argiropoulos B, Starczynowski DT, Karsan A, Heuser M, Hogge D, Camargo FD, Engelhardt S, Dohner H, Buske C, Jongen-Lavrencic M, Naldini L, Humphries RK & Kuchenbauer F. MicroRNA-223 dose levels fine tune proliferation and differentiation in human cord blood progenitors and acute myeloid leukemia. Exp Hematol 43:858-868 e857, 2015. View Abstract

Azoitei N, Diepold K, Brunner C, Rouhi A, Genze F, Becher A, Kestler H, van Lint J, Chiosis G, Koren J, 3rd, Frohling S, Scholl C & Seufferlein T. HSP90 supports tumor growth and angiogenesis through PRKD2 protein stabilization. Cancer Res 74:7125-7136, 2014. View Abstract

Rouhi A & Frohling S. Deregulation of the CDX2-KLF4 axis in acute myeloid leukemia and colon cancer. Oncotarget 4:174-175, 2013. View Abstract

Mulaw MA, Krause A, Deshpande AJ, Krause LF, Rouhi A, La Starza R, Borkhardt A, Buske C, Mecucci C, Ludwig WD, Lottaz C & Bohlander SK. CALM/AF10-positive leukemias show upregulation of genes involved in chromatin assembly and DNA repair processes and of genes adjacent to the breakpoint at 10p12. Leukemia 26:1012-1019, 2012. View Abstract

Grasedieck S, Scholer N, Bommer M, Niess JH, Tumani H, Rouhi A, Bloehdorn J, Liebisch P, Mertens D, Dohner H, Buske C, Langer C & Kuchenbauer F. Impact of serum storage conditions on microRNA stability. Leukemia 26:2414-2416, 2012. View Abstract

Starczynowski DT, Kuchenbauer F, Wegrzyn J, Rouhi A, Petriv O, Hansen CL, Humphries RK & Karsan A. MicroRNA-146a disrupts hematopoietic differentiation and survival. Exp Hematol 39:167-178 e164, 2011. View Abstract

Rouhi A & Buske C. Stem cells and beyond: report on the 40th Annual Scientific Meeting of the International Society of Experimental Hematology. Expert Rev Hematol 4:591-592, 2011. View Abstract

Kuchenbauer F, Mah SM, Heuser M, McPherson A, Ruschmann J, Rouhi A, Berg T, Bullinger L, Argiropoulos B, Morin RD, Lai D, Starczynowski DT, Karsan A, Eaves CJ, Watahiki A, Wang Y, Aparicio SA, Ganser A, Krauter J, Dohner H, Dohner K, Marra MA, Camargo FD, Palmqvist L, Buske C & Humphries RK. Comprehensive analysis of mammalian miRNA* species and their role in myeloid cells. Blood 118:3350-3358, 2011. View Abstract

Deshpande AJ, Rouhi A, Lin Y, Stadler C, Greif PA, Arseni N, Opatz S, Quintanilla-Fend L, Holzmann K, Hiddemann W, Dohner K, Dohner H, Xu G, Armstrong SA, Bohlander SK & Buske C. The clathrin-binding domain of CALM and the OM-LZ domain of AF10 are sufficient to induce acute myeloid leukemia in mice. Leukemia 25:1718-1727, 2011. View Abstract

Xiang P, Lo C, Argiropoulos B, Lai CB, Rouhi A, Imren S, Jiang X, Mager D & Humphries RK. Identification of E74-like factor 1 (ELF1) as a transcriptional regulator of the Hox cofactor MEIS1. Exp Hematol 38:798-798, 808 e791-792, 2010. View Abstract

Rogers SL, Zhao Y, Jiang X, Eaves CJ, Mager DL & Rouhi A. Expression of the leukemic prognostic marker CD7 is linked to epigenetic modifications in chronic myeloid leukemia. Mol Cancer 9:41, 2010. View Abstract

Reiss D, Zhang Y, Rouhi A, Reuter M & Mager DL. Variable DNA methylation of transposable elements: the case study of mouse Early Transposons. Epigenetics 5:68-79, 2010. View Abstract

Argiropoulos B, Palmqvist L, Imren S, Miller M, Rouhi A, Mager DL & Humphries RK. Meis1 disrupts the genomic imprint of Dlk1 in a NUP98-HOXD13 leukemia model. Leukemia 24:1788-1791, 2010. View Abstract

Rouhi A, Lai CB, Cheng TP, Takei F, Yokoyama WM & Mager DL. Evidence for high bi-allelic expression of activating Ly49 receptors. Nucleic Acids Res 37:5331-5342, 2009. View Abstract

Rouhi A, Mager DL, Humphries RK & Kuchenbauer F. MiRNAs, epigenetics, and cancer. Mamm Genome 19:517-525, 2008. View Abstract

Rouhi A, Brooks CG, Takei F & Mager DL. Plasticity of Ly49g expression is due to epigenetics. Mol Immunol 44:821-826, 2007. View Abstract

Rouhi A, Gagnier L, Takei F & Mager DL. Evidence for epigenetic maintenance of Ly49a monoallelic gene expression. J Immunol 176:2991-2999, 2006. View Abstract7

Rogers SL, Rouhi A, Takei F & Mager DL. A role for DNA hypomethylation and histone acetylation in maintaining allele-specific expression of mouse NKG2A in developing and mature NK cells. J Immunol 177:414-421, 2006. View Abstract

Landry JR, Rouhi A, Medstrand P & Mager DL. The Opitz syndrome gene Mid1 is transcribed from a human endogenous retroviral promoter. Mol Biol Evol 19:1934-1942, 2002. View Abstract