Principal Investigators


Dr Connie J Eaves — PhD, FRS(C)

Distinguished Scientist


Admin Contact

Alice Chau

Administrative Coordinator
Research Interest
Lab Members
  • Professor, Medical Genetics, UBC
  • Associate Member, Medicine, UBC
  • Associate Member, Pathology & Laboratory Medicine, UBC
  • Normal and Leukemic Stem Cells – Characterization and Regulation
  • Normal and Malignant Breast Stem Cells – Characterization and Regulation
  • Derivation of Hematopoietic Cells from Human Embryonic and Induced Pluripotent Stem Cells

Experiments in this laboratory and elsewhere have established the existence in adults (both mouse and man) of primitive hematopoietic stem cells capable of permanently reconstituting the production of mature blood cells in marrow-ablated or suppressed recipients. A major part of our work continues to focus on the development, validation and use of quantitative assays that are specific for biologically distinct subsets of these stem cells using syngeneic (mouse-mouse) and xenogeneic (human-mouse) hosts.   From large sets of in vitro and in vivo experiments of clonally monitored responses of individual highly purified stem cells, we have recently discovered two sources of their heterogeneous behaviour. One is determined by the complement of externally-derived signals to which the stem cells are exposed. The second appears to be intrinsically determined leading to a differentiation behavior that can be passed on with fidelity through many stem cell divisions. We have also identified a developmental “switch” that alters stem cell proliferation and self-renewal control in the post-natal period. We are now trying to elucidate the molecular mechanisms underlying each of these causes of variable stem cell behavior using defined culture systems, gene transfer strategies, and genome-wide gene expression analyses.

Another goal is to investigate the molecular basis of the altered behavior of the leukemic stem cells in patients with chronic myeloid leukemia, to develop new models of this disease in mice reconstituted with genetically modified human and murine stem cells and to identify new agents for their selective kill.

A third initiative is focused on extending the above approaches to the study of human breast cancer. We have pioneered the development of quantitative assays for normal mouse and human breast epithelial stem cells and these are being used to identify their distinguishing features and growth regulation. Studies to adapt these methods for application to human breast cancer are underway. The objective is to provide a basis for analyzing molecular and genetic determinants of breast cancer at the level of the breast cancer stem cell and thereby develop more rational, patient-targeted therapies.


Miller PH, Rabu G, MacAldaz M, Knapp DJHF, Cheung AM, Dhillon K, Nakamichi N, Beer PA, Schultz L, Humphries RK & Eaves CJ. Analysis of paramaters that affect human hematopoietic cell outputs in mutant c-kit immunodeficient mice. Exp Heamatol, in Press.

Knapp DJHF, Hammond CA, Miller PH, Rabu GM, Beer PA, Ricicova M, Lecault V, Da Costa D, VanInsberghe M, Cheung AM, Pellacani D, Piret J, Hansen C & Eaves CJ. Dissociation of survival, proliferation and state control in human hematopoietic stem cells. Stem Cell Reports 8:152-162, 2017. View Abstract


Pellacani D, Bilenky M, Kannan N, Heravi-Moussavi A, Knapp DJ, Gakkhar S, Moksa M, Carles A, Moore R, Mungall AJ, Marra MA, Jones SJ, Aparicio S, Hirst M & Eaves CJ. Analysis of normal human mammary epigenomes reveals cell-specific active enhancer states and associated transcription factor networks. Cell Rep 17:2060-2074, 2016. View Abstract

Knapp DJ, Hammond CA, Aghaeepour N, Miller PH, Pellacani D, Beer PA, Sachs K, Qiao W, Wang W, Humphries RK, Sauvageau G, Zandstra PW, Bendall SC, Nolan GP, Hansen C & Eaves CJ. Distinct signaling programs control human hematopoietic stem cell survival and proliferation. Blood [Epub ahead of print, Nov 8 2016]. View Abstract

Miller PH, Nakamichi N, Knapp DJHF, Rabu G, Schultz KR, Jones DM, Couban S, Eaves CJ. Quantitation of human cells that produce neutrophils and platelets in vivo obtained from normal donors treated with G-CSF and/or plerixafor. Biol Blood Marrow Transplant 22: 1945-1952,  2016. View Abstract

Lorzadeh A, Bilenky M, Hammond C, Knapp DJHF, Li L, Miller PH, Carles A, Heravi-Moussavi A, Gakkhar S, Moksa M, Eaves C & Hirst M. (2016). Nucleosome density ChIP-seq identifies distinct chromatin modification signatures associated with MNase accessibility. Cell Rep 17: 2112-2124. View Abstract

Miller PH, Knapp DJ, Beer PA, MacAldaz M, Rabu G, Cheung AM, Wei L & Eaves CJ. Early production of human neutrophils and platelets post-transplant is severely compromised by growth factor exposure. Exp Hematol 44: 635-40, 2016. View abstract


Nguyen LV*, Pellacani D*, Lefort S, Kannan N, Osako T, Makarem M, Cox CL, Kennedy W, Beer W, Carles A, Moksa M, Bilenky M, Balani S, Babovic S, Sun I, Rosin M, Aparicio S, Hirst M & Eaves CJ. Barcoding reveals complex clonal dynamics of de novo transformed human mammary cells. Nature 528: 267-71, 2015. *equal contribution. View Abstract

Sikorski DJ, Caron NJ, VanInsberghe M, Zahn H, Eaves CJ, Piret JM, Hansen CL. Clonal analysis of individual human embryonic stem cell differentiation patterns in microfluidic cultures. Biotechnol J 10: 1546-54, 2015. View Abstract

Patenaude A, Woerher S, Umlandt P, Wong F, Ibrahim R, Kyle A, Unger S, Fuller M, Parker J, Minchinton A, Eaves CJ & Karsan A. A Novel Population of Local Pericyte Precursor Cells in Tumor Stroma that Require Notch Signaling for Differentiation. Microvasc Res 101: 38-47, 2015.  View Abstract

Joshi PA, Waterhouse PD, Kannan N, Narala S, Fang H, Di Grappa MA, Jackson HW, Penninger JM, Eaves C & Khokha R. RANK Signaling Amplifies WNT-Responsive Mammary Progenitors through R-SPONDIN1. Stem Cell Reports 5: 31-44, 2015.  View Abstract

Cole A, Wang Z, Coyaud E, Voisin V, Gronda M, Jitkova Y, Mattson R, Hurren R, Babovic S, Maclean N, Restall I, Wang X, Jeyaraju DV, Sukhai MA, Prabha S, Bashir S, Ramakrishnan A, Leung E, Qia YH, Zhang N, Combes KR, Ketela T, Lin F, Houry WA, Aman A, Al-Awar R, Zheng W, Wienholds E, Xu CJ, Dick J, Wang JC, Moffat J, Minden MD, Eaves CJ, Bader GD, Hao Z, Kornblau SM, Raught B & Schimmer AD. Inhibition of the mitochondrial protease ClpP as a therapeutic strategy for human acute myeloid leukemia. Cancer Cell. 27:864-76, 2015. View Abstract

von Palffy S, Bulaeva E, Babovic S, Kannan N, Knapp D, Wei L, Eaves CJ, Beer P. Dominant negative IKAROS enhances IL-3-stimulated signaling in wild-type but not BCR-ABL1+ mouse BA/F3 cells. Exp Hematol. 43:514-523, 2015. View Abstract

Eirew P, Steif A, Khattra J, Ha G, Yap D, Farahani H, Gelmon K, Chia S, Mar C, Wan A, Laks E, Biele J, Shumansky K, Rosner J, McPherson A, Nielsen C, Roth AJ, Lefebvre C, Bashashati A, De Souza C, Siu C, Aniba R, Brimhall J, Oloumi A, Osako T, Bruna A, Sandoval JL, Algara T, Greenwood W, Leung K, Cheng H, Xue H, Wang Y, Lin D, Mungall AJ, Moore R, Zhao Y, Lorette J, Nguyen L, Huntsman D, Eaves CJ, Hansen C, Marra MA, Caldas C, Shah SP & Aparicio S. Dynamics of genomic clones in breast cancer patient xenografts at single-cell resolution. Nature 518:422-6, 2015. View Abstract

Eaves CJ. Hematopoietic stem cells: concepts, definitions, and the new reality. Blood 125:2605-2613, 2015. View Abstract

Beer PA, Knapp DJ, Miller PH, Kannan N, Sloma I, Heel K, Babovic S, Bulaeva E, Rabu G, Terry J, Druker BJ, Loriaux MM, Loeb KR, Radich JP, Erber WN & Eaves CJ. Disruption of IKAROS activity in primitive chronic phase CML cells mimics myeloid disease. Blood 125:504-515, 2015. View Abstract

Burleigh A, McKinney S, Poon S, Ng V, Wan A, Eirew P, Prentice L, Annab L, Barrett C, Brimhall J, Caldas C, Eaves C, Aparicio S & Yap D. A co-culture genome-wide RNAi screen with mammary epithelial cells reveals transmembrane signals required for growth and differentiation. Breast Cancer Res 17:4, 2015. View Abstract

Zhang X, Ma W, Cui J, Yao H, Zhou H, Ge Y, Xiao L, Hu X, Liu BH, Yang J, Li YY, Chen S, Eaves CJ, Wu D & Zhao Y. Regulation of p21 by TWIST2 contributes to its tumor-suppressor function in human acute myeloid leukemia. Oncogene 34: 3000-10, 2015. View Abstract


Nguyen LV, Cox C, Eirew P, Knapp DJHF, Pellacani D, Kannan N, Carles A, Moksa M, Balani S, Shah S, Hirst M, Aparicio S & Eaves CJ. DNA barcoding reveals diverse growth kinetics of human breast tumour subclones in serially passaged xenografts. Nature Comm 5:5871, 2014. View Abstract

Zhou H, Ge Y, Sun L, Ma W, Wu J, Zhang X, Hu X, Eaves CJ, Wu D & Zhao Y. Growth arrest specific 2 is up-regulated in chronic myeloid leukemia cells and required for their growth. PLoS One 9:e86195, 2014. View Abstract

Kannan N, Nguyen LV, Eaves CJ. Integrin β3 links therapy resistance and cancer stem cell properties. Nat Cell Biol. May;16(5):397-9, 2014. View Abstract

Wohrer S, Knapp DJ, Copley MR, Benz C, Kent DG, Rowe K, Babovic S, Mader H, Oostendorp RA, Eaves CJ. Distinct stromal cell factor combinations can separately control hematopoietic stem cell survival, proliferation, and self-renewal. Cell Rep. 7:1956-67, 2014. View Abstract

Lai CK, Moon Y, Kuchenbauer F, Starzcynowski DT, Argiropoulos B, Yung E, Beer P, Schwarzer A, Sharma A, Park G, Leung M, Lin G, Vollett S, Fung S, Eaves CJ, Karsan A, Weng AP, Humphries RK & Heuser M. Cell fate decisions in malignant hematopoiesis: leukemia phenotype is determined by distinct functional domains of the MN1 oncogene. PLoS One 19:e112671, 2014. View Abstract

Kannan N, Nguyen LV, Makarem M, Dong Y, Shih K, Eirew P, Raouf A, Emerman JT, Eaves CJ. Glutathione-dependent and -independent oxidative stress-control mechanisms distinguish normal human mammary epithelial cell subsets. Proc Natl Acad Sci 111:7789-94, 2014. View Abstract

Zhou H, Ge Y, Sun L, Ma W, Wu J, Zhang X, Hu X, Eaves CJ, Wu D, Zhao Y. Growth arrest specific 2 is up-regulated in chronic myeloid leukemia cells and required for their growth. PLoS One. 21;9(1):e86195, 2014. View Abstract

Nguyen LV, Makarem M, Carles A, Moksa M, Kannan N, Pandoh P, Eirew P, Osako T, Kardel M, Cheung AM, Kennedy W, Tse K, Zeng T, Zhao Y, Humphries RK, Aparicio S, Eaves CJ, Hirst M. Clonal Analysis via Barcoding Reveals Diverse Growth and Differentiation of Transplanted Mouse and Human Mammary Stem Cells. Cell Stem Cell. 6;14:253-63, 2014. View Abstract

Knapp DJ, Eaves CJ. Control of the hematopoietic stem cell state. Cell Res. 24(1):3-4, 2014. View Abstract 

Imren S, Heuser M, Gasparetto M, Beer PA, Norddahl GL, Xiang P, Chen L, Berg T, Rhyasen GW, Rosten P, Park G, Moon Y, Weng AP, Eaves CJ & Humphries RK. Modeling de novo leukemogenesis from human cord blood with MN1 and NUP98HOXD13. Blood 124:3608-3612, 2014. View Abstract

Fares I, Chagraoui J, Gareau Y, Gingras S, Ruel R, Mayotte N, Csaszar E, Knapp DJ, Miller P, Ngom M, Imren S, Roy DC, Watts KL, Kiem HP, Herrington R, Iscove NN, Humphries RK, Eaves CJ, Cohen S, Marinier A, Zandstra PW & Sauvageau G. Cord blood expansion. Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal. Science 345:1509-1512, 2014. View Abstract

Chakrabarti R, Wei Y, Hwang J, Hang X, Blanco MA, Choudhury A, Tiede B, Romano RA, DeCoste C, Mercatali L, Ibrahim T, Amadori D, Kannan N, Eaves CJ, Sinha S & Kang Y. ΔNp63 promotes stem cell activity in mammary gland development and basal-like breast cancer by enhancing Fzd7 expression and Wnt signaling.  Nat Cell Biol. 10:1004-15, 2014. View Abstract

Beer PA, Knapp DJHF, Kannan N, Miller PH, Babovic S, Bulaeva E, Aghaeepour N, Rabu G, Rostamirad S, Shih K, Wei L & Eaves CJ. A dominant-negative isoform of IKAROS expands primitive normal human hematopoietic cells. Stem Cell Reports. 3:1-17, 2014. View Abstract

Babovic S & Eaves CJ. Hierarchical organization of fetal and adult hematopoietic stem cells. Exp Cell Res 329:185-191, 2014. View Abstract


Copley MR, Eaves CJ. Developmental changes in hematopoietic stem cell properties. Exp Mol Med.  15;45:e55, 2013. View Abstract

Kawamura E, Fielding AB, Kannan N, Balgi A, Eaves CJ, Roberge M, Dedhar S. Identification of novel small molecule inhibitors of centrosome clustering in cancer cells. Oncotarget. 4:1763-76, 2013. View Abstract 

Sloma I, Beer PA, Saw KM, Chan M, Leung D, Raghuram K, Brimacombe C, Johnston B, Lambie K, Forrest D, Jiang X, Eaves CJ. Genotypic and functional diversity of phenotypically defined primitive hematopoietic cells in patients with chronic myeloid leukemia. Exp Hematol. 41:837-47, 2013 View Abstract

Copley MR, Babovic S, Benz C, Knapp DJ, Beer PA, Kent DG, Wohrer S, Treloar DQ, Day C, Rowe K, Mader H, Kuchenbauer F, Humphries RK, Eaves CJ. The Lin28b-let-7-Hmga2 axis determines the higher self-renewal potential of fetal haematopoietic stem cells. Nat Cell Biol. 15:916-25, 2013 View Abstract

Cheung AMS, Nguyen LV, Carles A, Beer PA, Miller PH, Knapp DJHF, Dhillon K, Hirst M & Eaves CJ. Analysis of the clonal growth and differentiation dynamics of primitive barcoded human cord blood cells in NSG mice. Blood 122:3129-37, 2013 View Abstract

Zeng F, Huang SZ, Gong ZJ, Chen MJ, Baldwin DA, Hu W, Qian H, Yan JB, Wang J, Xiao YP, Chalandon Y, Ringrose A, Ren ZR, Eaves A, Eaves C & Jiang X. Long-term deregulated human hematopoiesis in goats transplanted in utero with BCR-ABL-transduced lin(-)CD34(+) cord blood cells. Cell Res 23:859-862, 2013. View Abstract

Valent P, Bonnet D, Wöhrer S, Andreff M, Copland M, Chomienne C & Eaves C. Heterogeneity of neoplastic stem cells: theoretical, functional and clinical implications. Cancer Res 73:1037-1045, 2013. View Abstract

Tubsuwan A, Abed S, Deichmann A, Kardel MD, Bartholoma C, Cheung A, Negre O, Kadri Z, Fucharoen S, von Kalle C, Payen E, Chretien S, Schmidt M, Eaves CJ, Leboulch P & Maouche-Chretien L. Parallel assessment of globin lentiviral transfer in induced pluripotent stem cells and adult hematopoietic stem cells derived from the same transplanted beta-thalassemia patient. Stem Cells [Epub ahead of print May 27, 2013]. View Abstract

Sukhai MA, Prabha S, Hurren R, Rutledge AC, Lee AY, Sriskanthadevan S, Sun H, Wang X, Skrtic M, Seneviratne A, Cusimano M, Jhas B, Gronda M, Maclean N, Cho EE, Spagnuolo PA, Sharmeen S, Gebbia M, Urbanus M, Eppert K, Dissanayake D, Jonet A, Dassonville-Klimpt A, Li X, Datti A, Ohashi PS, Wranan J, Rogers I, Sonnet P, Ellis WY, Corey SJ, Eaves C, Minder MD, Wang JCY, Dick JE, Nislow C, Giaever G & Schimmer AD. Lysosomal disruption as a therapeutic strategy for acute myeloid leukemia. J Clin Invest 123:315-328, 2013. View Abstract

Sloma I, Beer PA, Saw KM, Chan M, Leung D, Raghuram K, Brimacombe C, Johnston B, Lambie K, Forrest D, Jiang X & Eaves CJ. Genotypic and functional diversity of phenotypically defined primitive hematopoietic cells in patients with chronic myeloid leukemia. Exp Hematol [Epub ahead of print, July 11, 2013].

Sloma I, Imren S, Beer P, Zhao Y, Lecault V, Leung D, Raghuram K, Brimacombe C, Lambie K, Piret J, Hansen C, Humphries RK & Eaves CJ. Ex vivo expansion of normal and chronic myeloid leukemic stem cells without functional alteration using a NUP98HOXA10homeodomain fusion gene. Leukemia 27:159-169, 2013. View Abstract

Miller PH, Knapp DJ & Eaves CJ. Heterogeneity in hematopoietic stem cell population: implications for transplantation. Curr Opin Hematol 23:859-862, 2013. View Abstract

Miller PH, Cheung AM, Beer PA, Knapp DJ, Dhillon K, Rabu G, Rostamirad S, Humphries RK & Eaves CJ. Enhanced normal short term human myelopoiesis in mice engineered to express human-specific myeloid growth factors. Blood 121:e1-4, 2013 View Abstract

Makarem M, Kannan N, Nguyen LV, Knapp DJHF, Balani S, Prater MD, Stingl J, Raouf A, Nemirovsky O, Eirew P & Eaves CJ. Developmental changes in the in vitro activated regenerative activity of primitive mammary epithelial cells. PLoS Biol 11:e1001630, 2013. View Abstract

Makarem M, Spike BT, Dravis C, Kannan N, Wahl GM & Eaves CJ. Stem cells and the developing mammary gland. J Mammary Gland Biol Neoplasia 18:209-219, 2013. View Abstract

Kannan N, Huda N, Tu L, Droumeva R, Aubert G, Chavez E, Brinkman RR, Lansdorp P, Emerman J, Abe S, Eaves C & Gilley D. The luminal progenitor compartment of the normal human mammary gland constitutes a unique site of telomere dysfunction. Stem Cell Reports 1:28-37, 2013.

Glauche I, Bystrykh L, Eaves C, Roeder I & and other participants. Stem cell clonality - Theoretical concepts, experimental techniques, and clinical challenges. Blood Cells Mol Dis 50:232-40, 2013. View Abstract

Valent P, Bonnet D, Wöhrer S, Andreff M, Copland M, Chomienne C & Eaves C. Heterogeneity of neoplastic stem cells: theoretical, functional and clinical implications.  Cancer Res 73:1037-1045, 2013. View Abstract

Aghaeepour N, Finak G, Dougall D, Hadj-Khodabakhshi A, Mah P, Obermoser G, Spidlen J, Taylor I, Wuensch SA, Bramson J, Eaves C, Weng AP, Fortuno ESI, Ho K, Kollmann T, Rogers W, De Rosa A, Dalal B, Azad A, Pothen A, Brandes A, Bretschneider H, Bruggner R, Finck R, Jia R, Zimmerman N, Linderman M, Dill D, Nolan G, Chan C, El Khettabi F, O'Neill K, Chikina M, Gupta A, Shooshtari P, Zare H, De Jager PL, Jiang M, Keilwagen J, Maisog JM, Majek P, Vilcek J, Maninen T, Huttunen H, Ruusuvouri P, Nykter M, McLachlan GJ, Wang K, Naim I, Sharma G, Nikolic R, Pyne S, Qian Y, Qiu P, Quinn J, Roth A, Norel R, Stolovitzky G, Meyer P, Saez-Rodriguez J, Bhattacharjee M, Biehl M, Bucher P, Bunte K, Di Camillo B, Dimitrieva S, Grau J, Grosse I, Posch S, Guex N, Keilwagen J, Kursa M, Liu B, Maienschein-Cline M, Manninen T, Schneider P, Seifert M, Strickert M, Vilar JMG, Hoos H, Mosmann T, Gottardo R, Brinkman R & Scheuermann RH. Critical assessment of automated flow cytometry analysis techniques. Nat Methods 10:228-38, 2013. View Abstract

Chen M, Gallipoli P, DeGeer D, Sloma I, Forrest DL, Chan M, Lai D, Jorgensen H, Ringrose A, Wang HM, Lambie K, Nakamoto H, Saw KM, Turhan A, Arlinghaus R, Barnett MJ, Eaves A, Eaves CJ, Holyoake TL & Jiang X. Targeting human chronic myeloid leukemia stem/progenitor cells by effective inhibition of a new AHI-1-BCR-ABL-JAK2 complex . J Natl Cancer Inst 105: 405-423, 2013. View Abstract

Sloma I, Imren S, Beer P, Zhao Y, Lecault V, Leung D, Raghuram K, Brimacombe C, Lambie K, Piret J, Hansen C, Humphries RK & Eaves CJ. Ex vivo expansion of normal and chronic myeloid leukemic stem cells without functional alteration using a NUP98HOXA10homeodomain fusion gene. Leukemia 27:159-169, 2013. View Abstract

Sukhai MA, Prabha S, Hurren R, Rutledge AC, Lee AY, Sriskanthadevan S, Sun H, Wang X, Skrtic M, Seneviratne A, Cusimano M, Jhas B, Gronda M, Maclean N, Cho EE, Spagnuolo PA, Sharmeen S, Gebbia M, Urbanus M, Eppert K, Dissanayake D, Jonet A, Dassonville-Klimpt A, Li X, Datti A, Ohashi PS, Wranan J, Rogers I, Sonnet P, Ellis WY, Corey SJ, Eaves C, Minder MD, Wang JCY, Dick JE, Nislow C, Giaever G & Schimmer AD. Lysosomal disruption as a therapeutic strategy for acute myeloid leukemia. J Clin Invest 123:315-328, 2013. View Abstract


Eirew P, Kannan N, Knapp DJ, Vaillant F, Emerman JT, Lindeman GJ, Visvader JE & Eaves CJ. Aldehyde dehydrogenase activity is a biomarker of primitive normal human mammary luminal cells.  Stem Cells 30: 344-348, 2012. View Abstract

Copley MR, Beer PA, Eaves CJ. Hematopoietic stem cell heterogeneity takes center stage. Cell Stem Cell 10: 690-697, 2012. View Abstract

Benz C, Copley MR, Kent DG, Wohrer S, Cortes A, Aghaeepour N, Ma E, Mader H, Rowe K, Day C, Treloar D, Brinkman RR & Eaves CJ. Hematopoietic stem cell subtypes expand differentially during development and display distinct lymphopoietic programs. Cell Stem Cell 10: 273-283, 2012. View Abstract

Giambra V, Jenkins CR, Wang H, Lam SH, Shevchuk OO, Nemirovsky O, Wai C, Gusscott S, Chiang MY, Aster JC, Humphries RK, Eaves C & Weng AP. NOTCH1 promotes T cell leukemia-initiating activity by RUNX-mediated regulation of PKC- θ and reactive oxygen species. Nat Med 18:1693-1698, 2012. View Abstract

Valent P, Bonnet D, De Maria R, Lapidot T, Copland M, Melo JV, Chomienne C, Ishikawa F, Schuringa JJ, Stassi G, Huntly B, Herrmann H, Soulier J, Roesch A, Schuurhuis GJ, Wöhrer S, Arock M, Zuber J, Cerny-Reiterer S, Johnsen HE, Andreeff M & Eaves C. Cancer stem cell definitions and terminiology: the devil is n the details. Nat Rev Cancer 12:767-775, 2012. View Abstract

Cheung AM, Leung D, Rostamirad S, Dhillon K, Miller PH, Droumeva R, Brinkman RR, Hogge D, Roy DC & Eaves CJ. Distinct but phenotypically heterogeneous human cell populations produce rapid recovery of platelets and neutrophils after transplantation. Blood 119: 3431-3439, 2012. View Abstract

Despeaux M, Chicanne G, Rouer E, De Toni-Costes F, Bertrand J, Mansat-De Mas V, Vergnolle N, Eaves C, Payrastre B, Girault JA & Racaud-Sultan C. Focal adhesion kinase splice variants maintain primitive acute myeloid leukemia cells through altered Wnt signaling. Stem Cells 30: 1597-1610, 2012. View Abstract

Kardel MD & Eaves CJ. Modeling human hematopoietic cell development from pluripotent stem cells. Exp Hematol 40: 601-611, 2012. View Abstract

Man CH, Fung TK, Ho C, Han HH, Chow HC, Ma AC, Choi WW, Lok S, Cheung AM, Eaves C, Kwong YL & Leung AY. Sorafenib treatment of FLT3-ITD+ acute myeloid leukemia: favorable initial outcome and mechanisms of subsequent nonresponsiveness associated with the emergence of a D835 mutation. Blood 119: 5133-5143, 2012. View Abstract

Nieborowska-Skorska M, Kopinski PK, Ray R, Hoser G, Ngaba D, Flis S, Cramer K, Reddy MM, Koptyra M, Penserga T, Glodkowska-Mrowka E, Bolton E, Holyoke TL, Eaves CJ, Cerny-Reiter S, Valent P, Hochhaus A, Hughes TP, van der Kuip H, Sattler M, Wiktor-Jedrzejczak C, Dorrance A, Stoklosa T, Williams DA & Skorski T. Rac2-MRC-cIII-generated ROS cause genomic instability in chronic myeloid leukemia stem cells and primitive progenitors. Blood 119: 4253-4263, 2012. View Abstract

Nguyen LV, Vanner R, Dirks P & Eaves CJ. Cancer stem cells – an evolving concept. Nat Rev Cancer 12: 133-143, 2012. View Abstract

Serber DW, Rogala A, Makarem M, Rosson GB, Simin K, Godfrey V, Van Dyke T, Eaves CJ &Bultman SJ. The BRG1 chromatin remodeler protects against ovarian cysts, uterine tumors, and mammary tumors in a lineage-specific manner. PLos One 7: e31346, 2012. View Abstract

Shah SP, Roth A, Goya R, Oloumi A, Ha G, Zhao Y, Turashvili G, Ding J, Tse K, Haffari G, Bashashati A, Prentice LM, Khattra J, Burleigh A, Yap D, Bernard V, McPherson A, Shumansky K, Crisan A, Giuliany R, Heravi-Moussavi A, Rosner J, Lai D, Birol I, Varhol R, Tam A, Dhalla N, Zeng T, Ma K, Chan SK, Griffith M, Moradian A, Cheng S-WG, Morin GB, Watson P, Gelmon K, Chia S, Chin S-F, Curtis C, Rueda OM, Pharoah PD, Damaraju S, Mackey J, Hoon K, Harkins T, Tadigotla V, Sigaroudinia M, Gascard P, Tlsty T, Costello JF, Meyer IM, Eaves CJ, Wasserman WW, Jones S, Huntsman D, Hirst M, Caldas C, Marra MA & Aparicio S. The clonal and mutational evolution spectrum of primary triple-negative breast cancers. Nature 486: 395-399, 2012. View Abstract


Eirew P, Kannan N, Knapp DJHF, Vaillant F, Emerman JT, Lindeman GJ, Visvader JE & Eaves CJ. Aldehyde dehydrogenase activity is a biomarker of primitive normal human mammary luminal cells. Stem Cells 30: 344-348, 2011. View abstract

Skrtic M, Sriskanthadevan S, Jhas B, Gebbia M, Wang X, Wang Z, Hurren R, Jitkova Y, Gronda M, Maclean N, Lai CK, Eberhard Y, Bartoszko J, Spagnuolo P, Rutledge AC, Datti A, Ketela T, Moffat J, Robinson BH, Cameron JH, Wrana J, Eaves CJ, Minden MD, Wang JCY, Dick JE, Humphries K, Nislow C, Giaever G, Schimmer AD. Inhibition of mitochondrial translation as a therapeutic strategy for acute myeloid leukemia. Cancer Cell 20: 674-678, 2011. View Abstract

Sekulovic S, Gasparetto M, Lecault V, Hoesli CA, Kent DG, Rosten P, Wan A, Brookes C, Hansen CL, Piret JM, Smith C, Eaves CJ, Humphries RK. Ontogeny stage-independent and high-level clonal expansion in vitro of mouse hematopoietic stem cells stimulated by an engineered NUP98-HOX fusion transcription factor. Blood 118: 4366-4376, 2011.  View Abstract

O'Conner MD, Wederell E, Robertson G, Delaney A, Morozova O, Poon SSS, Yap D, Fee J, Zhao Y, McDonald H, Zeng T, Hirst M, Marra MA, Aparicio SA & Eaves CJ. Retinoblastoma-binding proteins 4 and 9 are important for human pluripotent stem cell maintenance.  Exp Hematol 39: 866-879, 2011. View Abstract

Sekulovic S, Gylfadottir V, Vulto I, Gasparetto M, Even Y, Brookes C, Smith C, Eaves CJ, Lansdorp PM, Rossi FM & Humphries RK. Prolonged self-renewal activity unmasks telomerase control of telomere homeostasis and function of mouse hematopoietic stem cells. Blood 118: 1766-73, 2011. View Abstract

Kuchenbauer F, Mah S, Heuser M, McPherson AW, Ruschmann J, Rouhi A, Berg T, Bullinger L, Agiropoulos B, Morin RD, Lai D, Starczynowski D, Karsan A, Eaves CJ, Watahiki A, Wang Y, Aparicio S, Ganser A, Krauter J, Doehner H, Doehner K, Marra M, Camargo F, Palmqvist L, Buske C & Humphries RK. Comprehensive analysis of mammalian miRNA* species and their role in myeloid cells. Blood 118: 3350-3358, 2011. View Abstract

Lecault V, Vaninsberghe M, Sekulovic S, Knapp DJ, Wohrer S, Bowden W, Viel F, McLaughlin T, Jarandehei A, Miller MM, Falconnet D, White AK, Kent DG, Copley MR, Taghipour F, Eaves CJ, Humphries RK, Piret JM, Hansen CL. High-throughput analysis of single hematopoietic stem cell proliferation in microfluidic cell culture arrays. Nat Methods 22: 581-586, 2011. View abstract


Holland DG, Burleigh A, Git A, Goldgraben MA, Perez-Mancera PA, Chin SF, Hurtado A, Bruna A, Ali HR, Greenwood W, Dunning MJ, Samarajiwa S, Menon S, Rueda OM, Lynch AG, McKinney S, Ellis IO, Eaves CJ, Carroll JS, Curtis C, Aparicio S, Caldas C. ZNF703 is a common Luminal B breast cancer oncogene that differentially regulates luminal and basal progenitors in human mammary epithelium. EMBO Mol Med 3:167-80, 2011. View Abstract

O’Connor MD, Kardel MD & Eaves CJ. Functional assays for human embryonic stem cell pluripotency. Methods Mol Biol 690: 67-80, 2011. View Abstract


Eirew P, Stingl J & Eaves CJ. Quantitation of human mammary epithelial stem cells with in vivo regenerative properties using a subrenal capsule xenotransplantation assay. Nat Protoc 5:1945-1956, 2010. View Abstract

Martignani E, Eirew P, Accornero P, Eaves CJ & Baratta M. Human milk protein production in xenografts of genetically engineered bovine mammary epithelial stem cells.  PLoS ONE 5: e13372, 2010. View Abstract

Sloma I, Jiang X., Eaves AC & Eaves CJ. Insights into the stem cells of chronic myeloid leukemia.  Leukemia 24:1823-1833, 2010. View Abstract

Law JH, Li Y, To K, Wang M, Lambie K, Jones SJM, Eaves CJ & Dunn SE. Molecular decoy to the Y-box binding protein-1 suppresses the growth of breast and prostate cancer cells whilst sparing normal cell viability.  PLoS ONE 5: pii: e12661, 2010. View Abstract

Grant H, Jiang X, Stebbing J, Foroni L, Craddock C, Griffiths M, Clark RE, O'Brien S, Khorashad JS, Gerrard G, Wang L, Irving JA, Wang M, Karran L, Dyer MJ, Forrest D, Page K, Eaves CJ, Woolfson A. Analysis of BCR-ABL1 tyrosine kinase domain mutational spectra in primitive chronic myeloid leukemia cells suggests a unique mutator phenotype. Leukemia 24: 1817-1821, 2010. View Abstract

Petriv OI, Kuchenbauer F, Delaney AD, Lecault V, White A, Kent D, Marmolejo L, Heuser M, Berg T, Copley M, Ruschmann J, Sekulovic S, Benz C, Kuroda E, Ho V, Antignano F, Halim T, Giambra V, Krystal G, Takei CJ, Weng AP, Piret J, Eaves C, Marra MA, Humphries RK, Hansen CL. Comprehensive microRNA expression profiling of the hematopoietic hierarchy. Proc Natl Acad Sci USA 107:15443-8, 2010. View Abstract

Jiang X, Forrest D, Nicolini F, Turhan A, Guilhot J, Yip C, Holyoake T, Jorgensen H, Lambie K, Saw KM, Pang E, Vukovic R, Lehn P, Ringrose A, Yu M, Brinkman RR, Smith C, Eaves A, Eaves C. Properties of CD34+ CML stem/progenitor cells that correlate with different clinical responses to imatinib mesylate. Blood 116: 2112-2121, 2010. View Abstract

Eaves CJ & Humphries RK. Acute myeloid leukemia and the Wnt pathway.  N Engl J Med 362: 2326-2327, 2010. View Abstract

To K, Fotovati A, Reipas KM, Law JH, Hu K, Wang J, Astanehe A, Davies AH, Lee L, Stratford AL, Raouf A, Johnson P, Berquin IM, Royer HD, Eaves CJ & Dunn SE. Y-box binding protein-1 induces the expression of CD44 and CD49f leading to enhanced self-renewal, mammosphere growth, and drug resistance.  Cancer Res 70: 2840-2851, 2010. View Abstract

Rogers SL, Zhao Y, Jiang X, Eaves CJ, Mager DL, & Rouhi A. Expression of the leukemic prognostic marker CD7 is linked to epigenetic modifications in chronic myeloid leukemia. Mol Cancer 9 (1): 41, 2010. View Abstract


Tacke M, Ball CR, Schmidt M, Klingenberg S, Maurer B, Fessler S, Eaves C, von Kalle C, & Glimm H. The inherent differentiation program of short term hematopoietic repopulating cells changes during human ontogeny. Stem Cells Dev 19(5): 621-8, 2009. View Abstract

Aparicio S, & Eaves CJ. p53: a new kingpin in the stem cell arena. Cell 138 (6): 1060-2, 2009. View Abstract

Martignani E, Eirew P, Eaves C, & Baratta M. Functional identification of bovine mammary epithelial stem/progenitor cells. Vet Res Commun 33 Suppl 1: 101-3, 2009. View Abstract

Sloma I, & Eaves CJ. TEL me all. Cell Stem Cell 5 (1): 5-6, 2009. View Abstract

Lu M, Kardel MD, O’Connor MD, & Eaves CJ. Enhanced generation of hematopoietic cells from human hepatocarcinoma cell-stimulated human embryonic and induced pluripotent stem cells. Exp Hematol 37 (8): 924-36, 2009. View Abstract

Vercauteren SM, Bashashati A, Wu D, Brinkman RR, Eaves C, Eaves A, & Karsan A. Reduction in multi-lineage and erythroid progenitors distinguishes myelodysplastic syndromes from non-malignant cytopenias. Leuk Res 33 (12): 1636-42, 2009. View Abstract

Kent DG, Copley MR, Benz C, Wohrer S, Dykstra BJ, Ma E, Cheyne J, Zhao Y, Bowie MB, Gasparetto M, Delaney A, Smith C, Marra M, & Eaves CJ. Prospective isolation and molecular characterization of hematopoietic stem cells with durable self-renewal potential. Blood 113 (25): 6342-50, 2009. View Abstract

Hills M, Lucke K, Chavez EA, Eaves CJ, & Lansdorp PM. Probing the mitotic history and developmental stage of hematopoietic cells using single telomere length analysis (STELA). Blood 113 (23): 5765-75, 2009. View Abstract

Finkbeiner MR, Astanehe A, To K, Fotovati A, Davies AH, Zhao Y, Jiang H, Stratford AL, Shadeo A, Boccaccio C, Comoglio P, Mertens PR, Eirew P, Raouf A, Eaves CJ, & Dunn SE. Profiling YB-1 target genes uncovers a new mechanism for MET receptor regulation in normal and malignant human mammary cells. Oncogene 28 (11): 1421-31, 2009. View Abstract


Eaves CJ. Cancer stem cells: Here, there, everywhere? Nature 456 (7222): 581-2, 2008. View Abstract

Eirew P, Stingl J, Raouf A, Turashvili G, Aparicio S, Emerman JT, & Eaves CJ. A method for quantifying normal human mammary epithelial stem cells with in vivo regenerative ability. Nat Med 14 (12): 1384-9, 2008. View Abstract

Lee C, Dhillon J, Wang MY, Gao Y, Hu K, Park E, Astanehe A, Hung MC, Eirew P, Eaves CJ, & Dunn SE. Targeting YB-1 in HER-2 overexpressing breast cancer cells induces apoptosis via the mTOR/STAT3 pathway and suppresses tumor growth in mice. Cancer Res 68 (21): 8661-6, 2008. View Abstract

Salvagiotto G, Zhao Y, Vodyanik M, Ruotti V, Stewart R, Marra M, Thomson J, Eaves C, & Slukvin I. Molecular profiling reveals similarities and differences between primitive subsets of hematopoietic cells generated in vitro from human embryonic stem cells and in vivo during embryogenesis. Exp Hematol 36 (10): 1377-89, 2008. View Abstract

Cramer K, Nieborowska-Skorska M, Koptyra M, Slupianek A, Penserga ET, Eaves CJ, Aulitzky W, & Skorski T. BCR/ABL and other kinases from chronic myeloproliferative disorders stimulate single-strand annealing, an unfaithful DNA double-strand break repair. Cancer Res 68 (17): 6884-8, 2008. View Abstract

Starczynowski DT, Vercauteren S, Telenius A, Sung S, Tohyama K, Brooks-Wilson A, Spinelli JJ, Eaves CJ, Eaves AC, Horsman DE, Lam WL, & Karsan A. High-resolution whole genome tiling path array CGH analysis of CD34+ cells from patients with low-risk myelodysplastic syndromes reveals cryptic copy number alterations and predicts overall and leukemia-free survival. Blood 112 (8): 3412-24, 2008. View Abstract

Banuelos CA, Banath JP, MacPhail SH, Zhao J, Eaves CJ, O’Connor MD, Lansdorp PM, & Olive PL. Mouse but not human embryonic stem cells are deficient in rejoining of ionizing radiation-induced DNA double-strand breaks. DNA Repair (Amst) 7 (9): 1471-83, 2008. View Abstract

Raouf A, Zhao Y, To K, Stingl J, Delaney A, Barbara M, Iscove N, Jones S, McKinney S, Emerman J, Aparicio S, Marra M, & Eaves C. Transcriptome analysis of the normal human mammary cell commitment and differentiation process. Cell Stem Cell 3 (1): 109-18, 2008. View Abstract

Jiang X, Zhao Y, Forrest D, Smith C, Eaves A, & Eaves C. Stem cell biomarkers in chronic myeloid leukemia. Dis Markers 24 (4-5): 201-16, 2008. View Abstract

Lindeman GJ, Visvader JE, Smalley MJ, & Eaves CJ. The future of mammary stem cell biology: the power of in vivo transplants. Breast Cancer Res 10 (3): 402; author reply 403, 2008. View Abstract

Kent DG, Dykstra BJ, Cheyne J, Ma E, & Eaves CJ. Steel factor coordinately regulates the molecular signature and biologic function of hematopoietic stem cells. Blood 112 (3): 560-7, 2008. View Abstract

Forrest DL, Jiang X, Eaves CJ, & Smith CL. An approach to the management of chronic myeloid leukemia in British Columbia. Curr Oncol 15 (2): 90-7, 2008. View Abstract

Miller CL, Dykstra B, & Eaves CJ. Characterization of mouse hematopoietic stem and progenitor cells. Curr Protoc Immunol Chapter 22: Unit 22B 2, 2008. View Abstract

Kent D, Copley M, Benz C, Dykstra B, Bowie M, & Eaves C. Regulation of hematopoietic stem cells by the steel factor/KIT signaling pathway. Clin Cancer Res 14 (7): 1926-30, 2008. View Abstract

Goldman FD, Aubert G, Klingelhutz AJ, Hills M, Cooper SR, Hamilton WS, Schlueter AJ, Lambie K, Eaves CJ, & Lansdorp PM. Characterization of primitive hematopoietic cells from patients with dyskeratosis congenita. Blood 111 (9): 4523-31, 2008. View Abstract

Morin RD, O’Connor MD, Griffith M, Kuchenbauer F, Delaney A, Prabhu AL, Zhao Y, McDonald H, Zeng T, Hirst M, Eaves CJ, & Marra MA. Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells. Genome Res 18 (4): 610-21, 2008. View Abstract

O’Connor MD, Kardel MD, Iosfina I, Youssef D, Lu M, Li MM, Vercauteren S, Nagy A, & Eaves CJ. Alkaline phosphatase-positive colony formation is a sensitive, specific, and quantitative indicator of undifferentiated human embryonic stem cells. Stem Cells 26 (5): 1109-16, 2008. View Abstract


Kent D, Dykstra B, & Eaves C. Isolation and assessment of long-term reconstituting hematopoietic stem cells from adult mouse bone marrow. Curr Protoc Stem Cell Biol Chapter 2: Unit 2A 4, 2007. View Abstract

Ungrin M, O’Connor M, Eaves C, & Zandstra PW. Phenotypic analysis of human embryonic stem cells. Curr Protoc Stem Cell Biol Chapter 1: Unit 1B 3, 2007. View Abstract

Dykstra B, Kent D, Bowie M, McCaffrey L, Hamilton M, Lyons K, Lee SJ, Brinkman R, & Eaves C. Long-term propagation of distinct hematopoietic differentiation programs in vivo. Cell Stem Cell 1 (2): 218-29, 2007. View Abstract

Leong KG, Niessen K, Kulic I, Raouf A, Eaves C, Pollet I, & Karsan A. Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin. J Exp Med 204 (12): 2935-48, 2007. View Abstract

Christ O, Lucke K, Imren S, Leung K, Hamilton M, Eaves A, Smith C, & Eaves C. Improved purification of hematopoietic stem cells based on their elevated aldehyde dehydrogenase activity. Haematologica 92 (9): 1165-72, 2007. View Abstract

Ohta H, Sekulovic S, Bakovic S, Eaves CJ, Pineault N, Gasparetto M, Smith C, Sauvageau G, & Humphries RK. Near-maximal expansions of hematopoietic stem cells in culture using NUP98-HOX fusions. Exp Hematol 35 (5): 817-30, 2007. View Abstract

Hirst M, Delaney A, Rogers SA, Schnerch A, Persaud DR, O’Connor MD, Zeng T, Moksa M, Fichter K, Mah D, Go A, Morin RD, Baross A, Zhao Y, Khattra J, Prabhu AL, Pandoh P, McDonald H, Asano J, Dhalla N, Ma K, Lee S, Ally A, Chahal N, Menzies S, Siddiqui A, Holt R, Jones S, Gerhard DS, Thomson JA, Eaves CJ, & Marra MA. LongSAGE profiling of nine human embryonic stem cell lines. Genome Biol 8 (6): R113, 2007. View Abstract

Jiang X, Saw KM, Eaves A, & Eaves C. Instability of BCR-ABL gene in primary and cultured chronic myeloid leukemia stem cells. J Natl Cancer Inst 99 (9): 680-93, 2007. View Abstract

Zhao Y, Raouf A, Kent D, Khattra J, Delaney A, Schnerch A, Asano J, McDonald H, Chan C, Jones S, Marra MA, & Eaves CJ. A modified polymerase chain reaction-long serial analysis of gene expression protocol identifies novel transcripts in human CD34+ bone marrow cells. Stem Cells 25 (7): 1681-9, 2007. View Abstract

Jiang X, Smith C, Eaves A, & Eaves C. The challenges of targeting chronic myeloid leukemia stem cells. Clin Lymphoma Myeloma 7 Suppl 2: S71-80, 2007. View Abstract

Bowie MB, Kent DG, Dykstra B, McKnight KD, McCaffrey L, Hoodless PA, & Eaves CJ. Identification of a new intrinsically timed developmental checkpoint that reprograms key hematopoietic stem cell properties. Proc Natl Acad Sci U S A 104 (14): 5878-82, 2007. View Abstract

Jiang X, Zhao Y, Smith C, Gasparetto M, Turhan A, Eaves A, & Eaves C. Chronic myeloid leukemia stem cells possess multiple unique features of resistance to BCR-ABL targeted therapies. Leukemia 21 (5): 926-35, 2007. View Abstract

Bowie MB, Kent DG, Copley MR, & Eaves CJ. Steel factor responsiveness regulates the high self-renewal phenotype of fetal hematopoietic stem cells. Blood 109 (11): 5043-8, 2007. View Abstract

Khattra J, Delaney AD, Zhao Y, Siddiqui A, Asano J, McDonald H, Pandoh P, Dhalla N, Prabhu AL, Ma K, Lee S, Ally A, Tam A, Sa D, Rogers S, Charest D, Stott J, Zuyderduyn S, Varhol R, Eaves C, Jones S, Holt R, Hirst M, Hoodless PA, & Marra MA. Large-scale production of SAGE libraries from microdissected tissues, flow-sorted cells, and cell lines. Genome Res 17 (1): 108-16, 2007. View Abstract


Bowie MB, McKnight KD, Kent DG, McCaffrey L, Hoodless PA, & Eaves CJ. Hematopoietic stem cells proliferate until after birth and show a reversible phase-specific engraftment defect. J Clin Invest 116 (10): 2808-16, 2006. View Abstract

Chung YJ, Park BB, Kang YJ, Kim TM, Eaves CJ, & Oh IH. Unique effects of Stat3 on the early phase of hematopoietic stem cell regeneration. Blood 108 (4): 1208-15, 2006. View Abstract

Clarke MF, Dick JE, Dirks PB, Eaves CJ, Jamieson CH, Jones DL, Visvader J, Weissman IL, & Wahl GM. Cancer stem cells—perspectives on current status and future directions: AACR Workshop on cancer stem cells. Cancer Res 66 (19): 9339-44, 2006. View Abstract

Dykstra B, Ramunas J, Kent D, McCaffrey L, Szumsky E, Kelly L, Farn K, Blaylock A, Eaves C, & Jervis E. High-resolution video monitoring of hematopoietic stem cells cultured in single-cell arrays identifies new features of self-renewal. Proc Natl Acad Sci U S A 103 (21): 8185-90, 2006. View Abstract

Fischer M, Schmidt M, Klingenberg S, Eaves CJ, von Kalle C, & Glimm H. Short-term repopulating cells with myeloid potential in human mobilized peripheral blood do not have a side population (SP) phenotype. Blood 108 (6): 2121-3, 2006. View Abstract

Glover CH, Marin M, Eaves CJ, Helgason CD, Piret JM, & Bryan J. Meta-analysis of differentiating mouse embryonic stem cell gene expression kinetics reveals early change of a small gene set. PLoS Comput Biol 2 (11): e158, 2006. View Abstract

Jorgensen HG, Copland M, Allan EK, Jiang X, Eaves A, Eaves C, & Holyoake TL. Intermittent exposure of primitive quiescent chronic myeloid leukemia cells to granulocyte-colony stimulating factor in vitro promotes their elimination by imatinib mesylate. Clin Cancer Res 12 (2): 626-33, 2006. View Abstract

Sieburg HB, Cho RH, Dykstra B, Uchida N, Eaves CJ, & Muller-Sieburg CE. The hematopoietic stem compartment consists of a limited number of discrete stem cell subsets. Blood 107 (6): 2311-6, 2006. View Abstract

Stingl J, Raouf A, Eirew P, & Eaves CJ. Deciphering the mammary epithelial cell hierarchy. Cell Cycle 5 (14): 1519-22, 2006. View Abstract

Stingl J, Eirew P, Ricketson I, Shackleton M, Vaillant F, Choi D, Li HI, & Eaves CJ. Purification and unique properties of mammary epithelial stem cells. Nature 439 (7079): 993-7, 2006. View Abstract

Yang H, Eaves C, de Lima M, Lee MS, Champlin RE, McMannis JD, Robinson SN, Niu T, Decker WK, Xing D, Ng J, Li S, Yao X, Eaves AC, Jones R, Andersson BS, & Shpall EJ. A novel triple purge strategy for eliminating chronic myelogenous leukemia (CML) cells from autografts. Bone Marrow Transplant 37 (6): 575-82, 2006. View Abstract


Chalandon Y, Jiang X, Christ O, Loutet S, Thanopoulou E, Eaves A, & Eaves C. BCR-ABL-transduced human cord blood cells produce abnormal populations in immunodeficient mice. Leukemia 19 (3): 442-8, 2005. View Abstract

Eaves CJ. SDF-1 tells stem cells to mind their P’s and Z’s. J Clin Invest 115 (1): 27-9, 2005. View Abstract

Eisterer W, Jiang X, Christ O, Glimm H, Lee KH, Pang E, Lambie K, Shaw G, Holyoake TL, Petzer AL, Auewarakul C, Barnett MJ, Eaves CJ, & Eaves AC. Different subsets of primary chronic myeloid leukemia stem cells engraft immunodeficient mice and produce a model of the human disease. Leukemia 19 (3): 435-41, 2005. View Abstract

Glimm H, Schmidt M, Fischer M, Schwarzwaelder K, Wissler M, Klingenberg S, Prinz C, Waller CF, Lange W, Eaves CJ, & von Kalle C. Efficient marking of human cells with rapid but transient repopulating activity in autografted recipients. Blood 106 (3): 893-8, 2005. View Abstract

Glimm H, Schmidt M, Fischer M, Klingenberg S, Lange W, Waller CF, Eaves CJ, & von Kalle C. Evidence of similar effects of short-term culture on the initial repopulating activity of mobilized peripheral blood transplants assessed in NOD/SCID-beta2microglobulin(null) mice and in autografted patients. Exp Hematol 33 (1): 20-5, 2005. View Abstract

Jorgensen HG, Allan EK, Graham SM, Godden JL, Richmond L, Elliott MA, Mountford JC, Eaves CJ, & Holyoake TL. Lonafarnib reduces the resistance of primitive quiescent CML cells to imatinib mesylate in vitro. Leukemia 19 (7): 1184-91, 2005. View Abstract

Raouf A, Brown L, Vrcelj N, To K, Kwok W, Huntsman D, & Eaves CJ. Genomic instability of human mammary epithelial cells overexpressing a truncated form of EMSY. J Natl Cancer Inst 97 (17): 1302-6, 2005. View Abstract

Stingl J, Raouf A, Emerman JT, & Eaves CJ. Epithelial progenitors in the normal human mammary gland. J Mammary Gland Biol Neoplasia 10 (1): 49-59, 2005. View Abstract

Stingl J, Emerman JT, & Eaves CJ. Enzymatic dissociation and culture of normal human mammary tissue to detect progenitor activity. Methods Mol Biol 290: 249-63, 2005. View Abstract


Chalandon Y, Jiang X, Loutet S, Eaves AC, & Eaves CJ. Growth autonomy and lineage switching in BCR-ABL-transduced human cord blood cells depend on different functional domains of BCR-ABL. Leukemia 18 (5): 1006-12, 2004. View Abstract

Chaudhry MA, Bowen BD, Eaves CJ, & Piret JM. Empirical models of the proliferative response of cytokine dependent hematopoietic cell lines. Biotechnol Bioeng 88 (3): 348-58, 2004. View Abstract

Eaves C. Hematopoietic stem cells get closer to the bone. Nat Med 10 (10): 1042-4, 2004. View Abstract

Imren S, Fabry ME, Westerman KA, Pawliuk R, Tang P, Rosten PM, Nagel RL, Leboulch P, Eaves CJ, & Humphries RK. High-level beta-globin expression and preferred intragenic integration after lentiviral transduction of human cord blood stem cells. J Clin Invest 114 (7): 953-62, 2004. View Abstract

Jiang X, Zhao Y, Chan WY, Vercauteren S, Pang E, Kennedy S, Nicolini F, Eaves A, & Eaves C. Deregulated expression in Ph+ human leukemias of AHI-1, a gene activated by insertional mutagenesis in mouse models of leukemia. Blood 103 (10): 3897-904, 2004. View Abstract

Nicolini FE, Cashman JD, Hogge DE, Humphries RK, & Eaves CJ. NOD/SCID mice engineered to express human IL-3, GM-CSF and Steel factor constitutively mobilize engrafted human progenitors and compromise human stem cell regeneration. Leukemia 18 (2): 341-7, 2004. View Abstract

Oh IH, Fabry ME, Humphries RK, Pawliuk R, Leboulch P, Hoffman R, Nagel RL, & Eaves C. Expression of an anti-sickling beta-globin in human erythroblasts derived from retrovirally transduced primitive normal and sickle cell disease hematopoietic cells. Exp Hematol 32 (5): 461-9, 2004. View Abstract

Shier LR, Schultz KR, Imren S, Regan J, Issekutz A, Sadek I, Gilman A, Luo Z, Panzarella T, Eaves CJ, & Couban S. Differential effects of granulocyte colony-stimulating factor on marrow- and blood-derived hematopoietic and immune cell populations in healthy human donors. Biol Blood Marrow Transplant 10 (9): 624-34, 2004. View Abstract

Thanopoulou E, Cashman J, Kakagianne T, Eaves A, Zoumbos N, & Eaves C. Engraftment of NOD/SCID-beta2 microglobulin null mice with multilineage neoplastic cells from patients with myelodysplastic syndrome. Blood 103 (11): 4285-93, 2004. View Abstract

Uchida N, Dykstra B, Lyons K, Leung F, Kristiansen M, & Eaves C. ABC transporter activities of murine hematopoietic stem cells vary according to their developmental and activation status. Blood 103 (12): 4487-95, 2004. View Abstract


Eaves C, Jiang X, Eisterer W, Chalandon Y, Porada G, Zanjani E, & Eaves A. New models to investigate mechanisms of disease genesis from primitive BCR-ABL(+) hematopoietic cells. Ann N Y Acad Sci 996: 1-9, 2003. View Abstract

Eaves CJ. Manipulating hematopoietic stem cell amplification with Wnt. Nat Immunol 4 (6): 511-2, 2003. View Abstract

Feuring-Buske M, Gerhard B, Cashman J, Humphries RK, Eaves CJ, & Hogge DE. Improved engraftment of human acute myeloid leukemia progenitor cells in beta 2-microglobulin-deficient NOD/SCID mice and in NOD/SCID mice transgenic for human growth factors. Leukemia 17 (4): 760-3, 2003. View Abstract

Jiang X, Stuible M, Chalandon Y, Li A, Chan WY, Eisterer W, Krystal G, Eaves A, & Eaves C. Evidence for a positive role of SHIP in the BCR-ABL-mediated transformation of primitive murine hematopoietic cells and in human chronic myeloid leukemia. Blood 102 (8): 2976-84, 2003. View Abstract

Jorgensen HG, Allan EK, Jiang X, Liakopoulou E, Richmond L, Eaves CJ, Eaves AC, & Holyoake TL. Stage-specific alterations in serum levels of G-CSF in chronic myeloid leukaemia. Leukemia 17 (7): 1430-2, 2003. View Abstract

Maeda M, Uchida N, Eaves CJ, & Takei F. Slow receptor acquisition by NK cells regenerated in vivo fromtransplanted fetal liver or adult bone marrow stem cells. Exp Hematol 31 (11): 1015-8, 2003. View Abstract

Szilvassy SJ, Ragland PL, Miller CL, & Eaves CJ. The marrow homing efficiency of murine hematopoietic stem cells remains constant during ontogeny. Exp Hematol 31 (4): 331-8, 2003. View Abstract

Uchida N, Dykstra B, Lyons KJ, Leung FY, & Eaves CJ. Different in vivo repopulating activities of purified hematopoietic stem cells before and after being stimulated to divide in vitro with the same kinetics. Exp Hematol 31 (12): 1338-47, 2003. View Abstract


Audet J, Miller CL, Eaves CJ, & Piret JM. Common and distinct features of cytokine effects on hematopoietic stem and progenitor cells revealed by dose-response surface analysis. Biotechnol Bioeng 80 (4): 393-404, 2002. View Abstract

Buske C, Feuring-Buske M, Abramovich C, Spiekermann K, Eaves CJ, Coulombel L, Sauvageau G, Hogge DE, & Humphries RK. Deregulated expression of HOXB4 enhances the primitive growth activity of human hematopoietic cells. Blood 100 (3): 862-8, 2002. View Abstract

Cashman J, Clark-Lewis I, Eaves A, & Eaves C. Stromal-derived factor 1 inhibits the cycling of very primitive human hematopoietic cells in vitro and in NOD/SCID mice. Blood 99 (3): 792-9, 2002. View Abstract

Cashman J, Dykstra B, Clark-Lewis I, Eaves A, & Eaves C. Changes in the proliferative activity of human hematopoietic stem cells in NOD/SCID mice and enhancement of their transplantability after in vivo treatment with cell cycle inhibitors. J Exp Med 196 (9): 1141-9, 2002. View Abstract

Chalandon Y, Jiang X, Hazlewood G, Loutet S, Conneally E, Eaves A, & Eaves C. Modulation of p210(BCR-ABL) activity in transduced primary human hematopoietic cells controls lineage programming. Blood 99 (9): 3197-204, 2002. View Abstract

Eisterer W, Jiang X, Bachelot T, Pawliuk R, Abramovich C, Leboulch P, Hogge D, & Eaves C. Unfulfilled promise of endostatin in a gene therapy-xenotransplant model of human acute lymphocytic leukemia. Mol Ther 5 (4): 352-9, 2002. View Abstract

Glimm H, Tang P, Clark-Lewis I, von Kalle C, & Eaves C. Ex vivo treatment of proliferating human cord blood stem cells with stroma-derived factor-1 enhances their ability to engraft NOD/SCID mice. Blood 99 (9): 3454-7, 2002. View Abstract

Holyoake TL, Jiang X, Drummond MW, Eaves AC, & Eaves CJ. Elucidating critical mechanisms of deregulated stem cell turnover in the chronic phase of chronic myeloid leukemia. Leukemia 16 (4): 549-58, 2002. View Abstract

Imren S, Payen E, Westerman KA, Pawliuk R, Fabry ME, Eaves CJ, Cavilla B, Wadsworth LD, Beuzard Y, Bouhassira EE, Russell R, London IM, Nagel RL, Leboulch P, & Humphries RK. Permanent and panerythroid correction of murine beta thalassemia by multiple lentiviral integration in hematopoietic stem cells. Proc Natl Acad Sci U S A 99 (22): 14380-5, 2002. View Abstract

Jiang X, Ng E, Yip C, Eisterer W, Chalandon Y, Stuible M, Eaves A, & Eaves CJ. Primitive interleukin 3 null hematopoietic cells transduced with BCR-ABL show accelerated loss after culture of factor-independence in vitro and leukemogenic activity in vivo. Blood 100 (10): 3731-40, 2002. View Abstract

Miller CL, Imren S, Antonchuk J, Kalberer C, Fabry ME, Nagel RL, Humphries RK, & Eaves CJ. Feasibility of using autologous transplantation to evaluate hematopoietic stem cell-based gene therapy strategies in transgenic mouse models of human disease. Mol Ther 6 (3): 422-8, 2002. View Abstract

Nicolini FE, Imren S, Oh IH, Humphries RK, Leboulch P, Fabry ME, Nagel RL, & Eaves CJ. Expression of a human beta-globin transgene in erythroid cells derived from retrovirally transduced transplantable human fetal liver and cord blood cells. Blood 100 (4): 1257-64, 2002. View Abstract

Oh IH, & Eaves CJ. Overexpression of a dominant negative form of STAT3 selectively impairs hematopoietic stem cell activity. Oncogene 21 (31): 4778-87, 2002. View Abstract

Richmond LJ, Alcorn MJ, Pearson C, Cameron G, Thomas T, Eaves CJ, Eaves AC, & Holyoake TL. CML leukapheresis products can be enriched for CD34+ cells and simultaneously depleted of CD15+ cells using a simple Ab cocktail. Cytotherapy 4 (5): 407-13, 2002. View Abstract

Uchida N, Leung FY, & Eaves CJ. Liver and marrow of adult mdr-1a/1b(-/-) mice show normal generation, function, and multi-tissue trafficking of primitive hematopoietic cells. Exp Hematol 30 (8): 862-9, 2002. View Abstract


Audet J, Miller CL, Rose-John S, Piret JM, & Eaves CJ. Distinct role of gp130 activation in promoting self-renewal divisions by mitogenically stimulated murine hematopoietic stem cells. Proc Natl Acad Sci U S A 98 (4): 1757-62, 2001. View Abstract

Brummendorf TH, Rufer N, Holyoake TL, Maciejewski J, Barnett MJ, Eaves CJ, Eaves AC, Young N, & Lansdorp PM. Telomere length dynamics in normal individuals and in patients with hematopoietic stem cell-associated disorders. Ann N Y Acad Sci 938: 293-303; discussion 303-4, 2001. View Abstract

Buske C, Feuring-Buske M, Antonchuk J, Rosten P, Hogge DE, Eaves CJ, & Humphries RK. Overexpression of HOXA10 perturbs human lymphomyelopoiesis in vitro and in vivo. Blood 97 (8): 2286-92, 2001. View Abstract

Eaves C. The development and implementation of a crisis response team in a school setting. Int J Emerg Ment Health 3 (1): 35-46, 2001. View Abstract

Eaves C, Glimm H, Eisterer W, Audet J, Maguer-Satta V, & Piret J. Characterization of human hematopoietic cells with short-lived in vivo repopulating activity. Ann N Y Acad Sci 938: 63-70; discussion 70-1, 2001. View Abstract

Glimm H, Eisterer W, Lee K, Cashman J, Holyoake TL, Nicolini F, Shultz LD, von Kalle C, & Eaves CJ. Previously undetected human hematopoietic cell populations with short-term repopulating activity selectively engraft NOD/SCID-beta2 microglobulin-null mice. J Clin Invest 107 (2): 199-206, 2001. View Abstract

Holyoake TL, Jiang X, Jorgensen HG, Graham S, Alcorn MJ, Laird C, Eaves AC, & Eaves CJ. Primitive quiescent leukemic cells from patients with chronic myeloid leukemia spontaneously initiate factor-independent growth in vitro in association with up-regulation of expression of interleukin-3. Blood 97 (3): 720-8, 2001. View Abstract

Pawliuk R, Westerman KA, Fabry ME, Payen E, Tighe R, Bouhassira EE, Acharya SA, Ellis J, London IM, Eaves CJ, Humphries RK, Beuzard Y, Nagel RL, & Leboulch P. Correction of sickle cell disease in transgenic mouse models by gene therapy. Science 294 (5550): 2368-71, 2001. View Abstract

Stingl J, Eaves CJ, Zandieh I, & Emerman JT. Characterization of bipotent mammary epithelial progenitor cells in normal adult human breast tissue. Breast Cancer Res Treat 67 (2): 93-109, 2001. View Abstract

Uchida N, Fujisaki T, Eaves AC, & Eaves CJ. Transplantable hematopoietic stem cells in human fetal liver have a CD34(+) side population (SP)phenotype. J Clin Invest 108 (7): 1071-7, 2001. View Abstract


Brummendorf TH, Holyoake TL, Rufer N, Barnett MJ, Schulzer M, Eaves CJ, Eaves AC, & Lansdorp PM. Prognostic implications of differences in telomere length between normal and malignant cells from patients with chronic myeloid leukemia measured by flow cytometry. Blood 95 (6): 1883-90, 2000. View Abstract

Cashman JD, & Eaves CJ. High marrow seeding efficiency of human lymphomyeloid repopulating cells in irradiated NOD/SCID mice. Blood 96 (12): 3979-81, 2000. View Abstract

Croizat H, Ponchio L, Nicolini FE, Nagel RL, & Eaves CJ. Primitive haematopoietic progenitors in the blood of patients with sickle cell disease appear to be endogenously mobilized. Br J Haematol 111 (2): 491-7, 2000. View Abstract

Glimm H, Oh IH, & Eaves CJ. Human hematopoietic stem cells stimulated to proliferate in vitro lose engraftment potential during their S/G(2)/M transit and do not reenter G(0). Blood 96 (13): 4185-93, 2000. View Abstract

Hennemann B, Oh IH, Chuo JY, Kalberer CP, Schley PD, Rose-John S, Humphries RK, & Eaves CJ. Efficient retrovirus-mediated gene transfer to transplantable human bone marrow cells in the absence of fibronectin. Blood 96 (7): 2432-9, 2000. View Abstract

Hennemann B, Chuo JY, Schley PD, Lambie K, Humphries RK, & Eaves CJ. High-efficiency retroviral transduction of mammalian cells on positively charged surfaces. Hum Gene Ther 11 (1): 43-51, 2000. View Abstract

Hogge DE, Lambie K, Sutherland HJ, Benny WB, Dalal B, Currie C, Barnett MJ, Eaves AC, & Eaves CJ. Quantitation of primitive and lineage-committed progenitors in mobilized peripheral blood for prediction of platelet recovery post autologous transplant. Bone Marrow Transplant 25 (6): 589-98, 2000. View Abstract

Holyoake TL, Horrocks C, Thomas T, Eaves CJ, & Eaves AC. Cell separation improves the sensitivity of detecting rare human normal and leukemic hematopoietic cells in vivo in NOD/SCID mice. Cytotherapy 2 (6): 411-21, 2000. View Abstract

Jiang X, Fujisaki T, Nicolini F, Berger M, Holyoake T, Eisterer W, Eaves C, & Eaves A. Autonomous multi-lineage differentiation in vitro of primitive CD34+ cells from patients with chronic myeloid leukemia. Leukemia 14 (6): 1112-21, 2000. View Abstract

Kalberer CP, Pawliuk R, Imren S, Bachelot T, Takekoshi KJ, Fabry M, Eaves CJ, London IM, Humphries RK, & Leboulch P. Preselection of retrovirally transduced bone marrow avoids subsequent stem cell gene silencing and age-dependent extinction of expression of human beta-globin in engrafted mice. Proc Natl Acad Sci U S A 97 (10): 5411-5, 2000. View Abstract

Maguer-Satta V, Oostendorp R, Reid D, & Eaves CJ. Evidence that ceramide mediates the ability of tumor necrosis factor to modulate primitive human hematopoietic cell fates. Blood 96 (13): 4118-23, 2000. View Abstract

Oh IH, Lau A, & Eaves CJ. During ontogeny primitive (CD34(+)CD38(-)) hematopoietic cells show altered expression of a subset of genes associated with early cytokine and differentiation responses of their adult counterparts. Blood 96 (13): 4160-8, 2000. View Abstract

Oostendorp RA, Ghaffari S, & Eaves CJ. Kinetics of in vivo homing and recruitment into cycle of hematopoietic cells are organ-specific but CD44-independent. Bone Marrow Transplant 26 (5): 559-66, 2000. View Abstract

Oostendorp RA, Audet J, & Eaves CJ. High-resolution tracking of cell division suggests similar cell cycle kinetics of hematopoietic stem cells stimulated in vitro and in vivo. Blood 95 (3): 855-62, 2000. View Abstract

Zandstra PW, Lauffenburger DA, & Eaves CJ. A ligand-receptor signaling threshold model of stem cell differentiation control: a biologically conserved mechanism applicable to hematopoiesis. Blood 96 (4): 1215-22, 2000. View Abstract


Sneha Balani

Graduate Student

Elizabeth Bulaeva

Graduate Student

Chien Chao

Directed Studies Student
Vancouver, BC --  29 November 2013 - Glenn Edin   (Photo: BC Cancer Agency)

Glenn Edin

Research Assistant

Margaret Hale

Cancer Research Technologist

Colin Hammond

Graduate Student
Vancouver, BC --  29 November 2013 - Naoto Nakamichi  (Photo: BC Cancer Agency)

Dr Naoto Nakamichi

Postdoctoral Fellow

Dr Davide Pellacani

Postdoctoral Fellow

Darcy Wilkinson

Research Assistant