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Principal Investigators

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Dr. Florian Kuchenbauer — MD, PhD

Senior Scientist

Laboratory Contact

Dr. Arefeh Rouhi

Staff Scientist
  604-675-8134

Admin Contact

Amy Yu

Research Projects Manager
  604-675-8128
Overview
Research Interest
Publications
Lab Members
Open Positions

Professional Experience

Education

  • MD, Medicine, Ludwig-Maximilians-University, Munich, Germany, 04/2001
  • MD Thesis, Neuro-Endocrinology, Max-Planck-Institute for Psychiatry,  Munich, Germany, 05/2002
  • Medical Resident, Department of Internal Medicine III, Klinikum Grosshadern, Munich, Germany, 06/2001-08/2005
  • PhD, Experimental Medicine, University of British Columbia, Canada, 10/2009
  • Medical Resident/Group Leader, Department of Internal Medicine III, University Hospital of Ulm, Germany, 08/2009-07/2013
  • Residency, Board examination for Internal Medicine, Ulm, Germany, 12/2013
  • Internal Medicine, Bone Marrow Transplantation Unit, Habilitation Internal Medicine, Ulm, Germany, 05/2017

As a scientist, the work of my laboratory has focused on non-coding RNAs, especially microRNAs (miRNAs) in acute myeloid leukemia (AML) and normal hematopoiesis. As a physician, I specialized in hematopoietic stem cell transplantation (HSCT) in adults, where I developed a clinical interest in optimizing current treatment protocols such as conditioning regimens for HSCT.

Our current research is mainly translational and focuses on interactions between the stem cell niche and allogenic stem cell transplantation, mechanisms of leukemogenesis as well as innovative treatment strategies for multiple myeloma. We are driven to improve patients´ lives by addressing clinical “every day” challenges with state-of-the-art research including preclinical animal models and to translate our research into clinically applicable therapies.

Wais V, Bunjes D, Kuchenbauer F & Sorror ML. Comorbidities, age, and other patient-related predictors of allogeneic hematopoietic cell transplantation outcomes. Expert Rev Hematol 1-12, 2018. View Abstract

Bommer M, Wolfle-Guter M, Bohl S & Kuchenbauer F. The Differential Diagnosis and Treatment of Thrombotic Microangiopathies. Dtsch Arztebl Int 115:327-334, 2018. View Abstract

Mathew NR, Baumgartner F, Braun L, ...,  Kuchenbauer F, ... & Zeiser R. Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD mutant leukemia cells. Nat Med 24:282-291, 2018. View Abstract

Xiang P, Wei W, Hofs N, Clemans-Gibbon J, Maetzig T, Lai CK, Dhillon I, May C, Ruschmann J, Schneider E, Rosten P, Hu K,  Kuchenbauer F, Hoodless PA & Humphries KR. A knock-in mouse strain facilitates dynamic tracking and enrichment of MEIS1. Blood Advances 24: 2225-2235, 2017. View Abstract

Kronke J,  Kuchenbauer F, Kull M, Teleanu V, Bullinger L, Bunjes D, Greiner A, Kolmus S, Kopff S, Schreder M, Mugge LO, Straka C, Engelhardt M, Dohner H, Einsele H, Bassermann F, Bargou R, Knop S & Langer C. IKZF1 expression is a prognostic marker in newly diagnosed standard-risk multiple myeloma treated with lenalidomide and intensive chemotherapy: a study of the German Myeloma Study Group (DSMM). Leukemia 31: 1363-1367, 2017. View Abstract

Wolf C, Garding A, Filarsky K, Bahlo J, Robrecht S, Becker N, Zucknick M, Rouhi A, Weigel A, Claus R, Weichenhan D, Eichhorst B, Fischer K, Hallek M,  Kuchenbauer F, Plass C, Dohner H, Stilgenbauer S, Lichter P & Mertens D. NFATC1 activation by DNA hypomethylation in chronic lymphocytic leukemia correlates with clinical staging and can be inhibited by ibrutinib. Int J Cancer 142: 322-333, 2018. View Abstract

Grasedieck S, Mulaw M, Sperb N, Wessinger K, Rouhi A, Bommer M, Bromberg JEC, Otto M, Tumani H, von Arnim CAF, Mertens D & Kuchenbauer F. Comprehensive microRNA expression profiling in cerebrospinal fluid distinguishes between neurological disease classes. Neuropathol Appl Neurobiol 2018. View PubMed Link

Kuchenbauer F & Buske C. Revisiting thrombocytopenia in acute promyelocytic leukemia. Leukemia 32:1477-1478, 2018.  (Comment) View PubMed Link

Wais V, Kundgen L, Bohl SR, von Harsdorf S, Schlenk RF, Dohner K, Teleanu V, Bullinger L, Nguyen TM, Drognitz K, Moulin JC, Binnenhei M, Bentz M, Dohner H, Bunjes D,  Kuchenbauer F & Ringhoffer M. Reduced-toxicity conditioning for allogeneic hematopoietic cell transplantation in elderly or comorbid patients with AML using fludarabine, BCNU and melphalan: disease stage at transplant determines outcome. Bone Marrow Transplant 53:94-96, 2018. View Abstract

Schneider E, Staffas A, Rohner L, Malmberg ED, Ashouri A, Krowiorz K, Pochert N, Miller C, Wei SY, Arabanian L, Buske C, Dohner H, Bullinger L, Fogelstrand L, Heuser M, Dohner K, Xiang P, Ruschmann J, Petriv OI, Heravi-Moussavi A, Hansen CL, Hirst M, Humphries RK, Rouhi A, Palmqvist L &  Kuchenbauer F. MicroRNA-155 is a direct target of Meis1, but not a driver in acute myeloid leukemia. Haematologica 103:246-255, 2018. View Abstract

Jyotsana N, Sharma A, Chaturvedi A, Scherr M,  Kuchenbauer F, Sajti L, Barchanski A, Lindner R, Noyan F, Suhs KW, Grote-Koska D, Brand K, Vornlocher HP, Stanulla M, Bornhauser B, Bourquin JP, Eder M, Thol F, Ganser A, Humphries RK, Ramsay E, Cullis P & Heuser M. RNA interference efficiently targets human leukemia driven by a fusion oncogene in vivo. Leukemia 32:224-226, 2018. View Abstract

Bhayadia R, Krowiorz K, Haetscher N, Jammal R, Emmrich S, Obulkasim A, Fiedler J, Schwarzer A, Rouhi A, Heuser M, Wingert S, Bothur S, Dohner K, Matzig T, Ng M, Reinhardt D, Dohner H, Zwaan CM, van den Heuvel Eibrink M, Heckl D, Fornerod M, Thum T, Humphries RK, Rieger MA, Kuchenbauer F & Klusmann JH. Endogenous Tumor Suppressor microRNA-193b: Therapeutic and Prognostic Value in Acute Myeloid Leukemia. J Clin Oncol 36:1007-1016, 2018. View Abstract

Staffas A, Arabanian LS, Wei SY, Jansson A, Stahlman S, Johansson P, Fogelstrand L, Cammenga J,  Kuchenbauer F & Palmqvist L. Upregulation of Flt3 is a passive event in Hoxa9/Meis1-induced acute myeloid leukemia in mice. Oncogene 36: 1516-1524, 2017. View Abstract

Schwarzer A, Emmrich S, Schmidt F, Beck D, Ng M, Reimer C, Adams FF, Grasedieck S, Witte D, Kabler S, Wong JWH, Shah A, Huang Y, Jammal R, Maroz A, Jongen-Lavrencic M, Schambach A,  Kuchenbauer F, Pimanda JE, Reinhardt D, Heckl D & Klusmann JH. The non-coding RNA landscape of human hematopoiesis and leukemia. Nat Commun 8: 218 2017. View Abstract

Rouhi A, Miller C, Grasedieck S, Reinhart S, Stolze B, Dohner H,  Kuchenbauer F, Bullinger L, Frohling S & Scholl C. Prospective identification of resistance mechanisms to HSP90 inhibition in KRAS mutant cancer cells. Oncotarget 8: 7678-7690, 2017. View Abstract

Rouhi A &  Kuchenbauer F. FOXtrotting with PUMILIOs. Blood 129: 2459-2460, 2017. View PubMed Link

Mohr S, Doebele C, Comoglio F, Berg T, Beck J, Bohnenberger H, Alexe G, Corso J, Stroebel P, Wachter A, Beissbarth T, Schnuetgen F, Cremer A, Haetscher N, Goellner S, Rouhi A, Palmqvist L, Rieger MA, Schroeder T, Bonig H, Mueller-Tidow C,  Kuchenbauer F, Schuetz E, Green AR, Urlaub H, Stegmaier K, Humphries RK, Serve H & Oellerich T. Hoxa9 and Meis1 cooperatively induce addiction to Syk signaling by suppressing miR-146a in acute myeloid leukemia. Cancer Cell 31: 549-562, 2017. View Abstract

Itkin T, Kumari A, Schneider E, Gur-Cohen S, Ludwig C, Brooks R, Kollet O, Golan K, Khatib-Massalha E, Russo CM, Chisholm JD, Rouhi A, Geiger H, Hornstein E, Kerr WG,  Kuchenbauer F & Lapidot T. MicroRNA-155 promotes G-CSF-induced mobilization of murine hematopoietic stem and progenitor cells via propagation of CXCL12 signaling. Leukemia 31: 1247-1250, 2017. View PubMed Link

Hirsch S, Blatte TJ, Grasedieck S, Cocciardi S, Rouhi A, Jongen-Lavrencic M, Paschka P, Kronke J, Gaidzik VI, Dohner H, Schlenk RF,  Kuchenbauer F, Dohner K, Dolnik A & Bullinger L. Circular RNAs of the nucleophosmin (NPM1) gene in acute myeloid leukemia. Haematologica 102: 2039-2047, 2017. View Abstract

Herzig JK, Bullinger L, Tasdogan A, Zimmermann P, Schlegel M, Teleanu V, Weber D, Rucker FG, Paschka P, Dolnik A, Schneider E,  Kuchenbauer F, Heidel FH, Buske C, Dohner H, Dohner K & Gaidzik VI. Protein phosphatase 4 regulatory subunit 2 (PPP4R2) is recurrently deleted in acute myeloid leukemia and required for efficient DNA double strand break repair. Oncotarget 8: 95038-95053, 2017. View Abstract

Bohl SR,  Kuchenbauer F, von Harsdorf S, Kloevekorn N, Schonsteiner SS, Rouhi A, Schwarzwalder P, Dohner H, Bunjes D & Bommer M. Thrombotic Microangiopathy after Allogeneic Stem Cell Transplantation: A Comparison of Eculizumab Therapy and Conventional Therapy. Biol Blood Marrow Transplant 23: 2172-2177, 2017. View Abstract

Shivarov V, Dolnik A, Lang KM, Kronke J,  Kuchenbauer F, Paschka P, Gaidzik VI, Dohner H, Schlenk RF, Dohner K & Bullinger L. MicroRNA expression-based outcome prediction in acute myeloid leukemia: novel insights through cross-platform integrative analyses. Haematologica 101: e454-e456 2016. View PubMed Link

Schneider E, Staffas A, Rohner L, Krowiorz K, Heuser M, Dohner K, Bullinger L, Dohner H, Fogelstrand L, Rouhi A,  Kuchenbauer F & Palmqvist L. MicroRNA-155 is upregulated in MLL-rearranged AML but its absence does not affect leukemia development. Exp Hematol 44: 1166-1171, 2016. View Abstract

Krowiorz K, Ruschmann J, Lai C, Ngom M, Maetzig T, Martins V, Scheffold A, Schneider E, Pochert N, Miller C, Palmqvist L, Staffas A, Mulaw M, Bohl SR, Buske C, Heuser M, Kraus J, O'Neill K, Hansen CL, Petriv OI, Kestler H, Dohner H, Bullinger L, Dohner K, Humphries RK, Rouhi A &  Kuchenbauer F. MiR-139-5p is a potent tumor suppressor in adult acute myeloid leukemia. Blood Cancer J 6 (Suppl. 12): e508 2016. View PubMed Link

Bohl S, von Harsdorf S, Mulaw M, Hofmann S, Babiak A, Maier CP, Schnell J, Hutter-Kronke LM, Scholl K, Wais V, Schlenk RF, Bullinger L, Ringhoffer M, Dohner H, Bunjes D, Bommer M &  Kuchenbauer F. Strong impact of extramedullary involvement in high-risk AML patients with active disease receiving the FLAMSA conditioning regimen for HSCT. Bone Marrow Transplant 51: 994-996, 2016. View Abstract

Sharma A, Yun H, Jyotsana N, Chaturvedi A, Schwarzer A, Yung E, Lai CK,  Kuchenbauer F, Argiropoulos B, Gorlich K, Ganser A, Humphries RK & Heuser M. Constitutive IRF8 expression inhibits AML by activation of repressed immune response signaling. Leukemia 29: 57-68, 2015. View Abstract

Gentner B, Pochert N, Rouhi A, Boccalatte F, Plati T, Berg T, Sun SM, Mah SM, Mirkovic-Hösle M, Ruschmann J, Muranyi A, Leierseder S, Argiropoulos B, Starczynowski DT, Karsan A, Heuser M, Hogge D, Camargo FD, Engelhardt S, Döhner H, Buske C, Jongen-Lavrencic M, Naldani L, Humphries RK &  Kuchenbauer F. MicroRNA-223 dose-levels fine-tune proliferation and differentiation in human cord blood progenitors and acute myeloid leukemia. Exp Hematol 43: 858-868, 2015. View Abstract

Lai CK, Moon Y,  Kuchenbauer F, Starzcynowski DT, Argiropoulos B, Yung E, Beer P, Schwarzer A, Sharma A, Park G, Leung M, Lin G, Vollett S, Fung S, Eaves CJ, Karsan A, Weng AP, Humphries RK & Heuser M. Cell fate decisions in malignant hematopoiesis: leukemia phenotype is determined by distinct functional domains of the MN1 oncogene. PLoS One 19: e112671 2014. View Abstract

Bilan V, Allegra D,  Kuchenbauer F & Mertens D. In vivo processing assay based on a dual-luciferase reporter system to evaluate DROSHA enzymatic activity. Methods Mol Biol 1095: 87-93, 2014. View Abstract

Allegra D, Bilan V, Garding A, Dohner H, Stilgenbauer S,  Kuchenbauer F, Mertens D & Zucknick M. Defective DROSHA processing contributes to downregulation of MiR-15/-16 in chronic lymphocytic leukemia. Leukemia 28: 98-107, 2014. View Abstract

Kumar M, Witt B, Knippschild U, Koch S, Meena JK, Heinlein C, Weise JM, Krepulat F,  Kuchenbauer F, Iben S, Rudolph KL, Deppert W & Gunes C. CEBP factors regulate telomerase reverse transcriptase promoter activity in whey acidic protein-T mice during mammary carcinogenesis. Int J Cancer 132: 2032-2043, 2013. View Abstract

Grasedieck S, Sorrentino A, Langer C, Buske C, Dohner H, Mertens D &  Kuchenbauer F. Circulating microRNAs in hematological diseases: principles, challenges, and perspectives. Blood 121: 4977-4984, 2013. View Abstract

Copley MR, Babovic S, Benz C, Knapp DJHF, Beer PA, Kent DG, Wohrer S, Treloar DQ, Day C, Rowe K, Mader H,  Kuchenbauer F, Humphries RK & Eaves CJ. The Lin28b-let-7-Hgma2 axis determines the higher self-renewal potential of fetal haematopoietic stem cells. Nat Cell Biol 15: 916-925, 2013. View Abstract

Langer C, Rucker FG, Buske C, Dohner H &  Kuchenbauer F. Targeted therapies through microRNAs: pulp or fiction? Ther Adv Hematol 3: 97-104, 2012. View PubMed Link

Gusscott S,  Kuchenbauer F, Humphries RK & Weng AP. Notch-mediated repression of miR-223 contributes to IGF1R regulation in T-ALL. Leuk Res 36: 905-911, 2012. View Abstract

Grasedieck S, Scholer N, Bommer M, Niess JH, Tumani H, Rouhi A, Bloehdorn J, Liebisch P, Mertens D, Dohner H, Buske C, Langer C &  Kuchenbauer F. Impact of serum storage conditions on microRNA stability. Leukemia 26: 2414-2416, 2012. View PubMed Link

Gasparetto M, Sekulovic S, Brocker C, Tang P, Zakaryan A, Xiang P,  Kuchenbauer F, Wen M, Katayoon K, Witty MF, Rosten P, Chen Y, Imren S, Duester G, Thompson DC, Humphries RK, Vasiliou V & Smith C. Aldehyde dehydrogenases are regulators of hematopoietic stem cell numbers and B-cell development. Exp Hematol 40: 318-329, 2012. View Abstract

Scholer N, Langer C &  Kuchenbauer F. Circulating microRNAs as biomarkers - True Blood? Genome Med 3: 72, 2011. View Abstract

Kuchenbauer F, Mah S, Heuser M, McPherson AW, Ruschmann J, Rouhi A, Berg T, Bullinger L, Agiropoulos B, Morin RD, Lai D, Starczynowski D, Karsan A, Eaves CJ, Watahiki A, Wang Y, Aparicio S, Ganser A, Krauter J, Doehner H, Doehner K, Marra M, Camargo F, Palmqvist L, Buske C & Humphries RK. Comprehensive analysis of mammalian miRNA* species and their role in myeloid cells. Blood 118: 3350-3358, 2011. View Abstract

Heuser M, Yun H, Berg T, Yung E, Argiropoulos B,  Kuchenbauer F, Park G, Hamwi I, Palmqvist L, Lai C, Leung M, Lin G, Chaturvedi A, Thakur BK, Iwasaki M, Bilenky M, Thiessen N, Robertson G, Hirst M, Kent D, Wilson NK, Gottgens B, Eaves C, Cleary ML, Marra M, Ganser A & Humphries RK. Cell of origin in AML: Susceptibility to MN1-induced transformation is regulated by the MEIS1/AbdB-like HOX protein complex. Cancer Cell 20: 39-52, 2011. View Abstract

Starczynowski DT, Morin R, McPherson A, Lam J, Chari R, Wegrzyn J,  Kuchenbauer F, Hirst M, Tohyama K, Humphries RK, Lam WL, Marra M & Karsan A. Genome-wide identification of human microRNAs located in leukemia-associated genomic alterations. Blood 117: 595-604, 2010. View Abstract

Starczynowski DT,  Kuchenbauer F, Wegrzyn J, Rouhi A, Petriv O, Hansen CL, Humphries RK & Karsan A. MicroRNA-146a disrupts hematopoietic differentiation and survival. Exp Hematol 39: 167-178, 2010. View Abstract

Starczynowski DT,  Kuchenbauer F, Argiropoulos B, Sung S, Morin R, Muranyi A, Hirst M, Hogge D, Marra M, Wells RA, Buckstein R, Lam W, Humphries RK & Karsan A. Identification of miR-145 and miR-146a as mediators of the 5q-syndrome phenotype. Nat Med 16: 49-58, 2010. View Abstract

Schöler N, Langer C, Dohner H, Buske C &  Kuchenbauer F. Serum microRNAs as a novel class of biomarkers: a comprehensive review of the literature. Exp Hematol 38: 1126-1130, 2010. View Abstract

Petriv OI,  Kuchenbauer F, Delaney AD, Lecault V, White A, Kent D, Marmolejo L, Heuser M, Berg T, Copley M, Ruschmann J, Sekulovic S, Benz C, Kuroda E, Ho V, Antignano F, Halim T, Giambra V, Krystal G, Takei F, Weng AP, Piret J, Eaves C, Marra MA, Humphries RK & Hansen CL. Comprehensive microRNA expression profiling of the hematopoietic hierarchy. Proc Natl Acad Sci USA 107: 15443-15448, 2010. View Abstract

Morin RD, Johnson NA, Severson TM, Mungall AJ, An J, Goya R, Paul JE, Boyle M, Woolcock BW,  Kuchenbauer F, Yap D, Humphries RK, Griffith OL, Shah S, Zhu H, Kimbara M, Shashkin P, Charlot JF, Tcherpakov M, Corbett R, Tam A, Varhol R, Smailus D, Moksa M, Zhao Y, Delaney A, Qian H, Birol I, Schein J, Moore R, Holt R, Horsman DE, Connors JM, Jones S, Aparicio S, Hirst M, Gascoyne RD & Marra MA. Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin. Nat Genet 42: 181-185, 2010. View Abstract

Heuser M, Park G, Moon Y, Berg T, Xiang P,  Kuchenbauer F, Vollett S, Lai C & Humphries RK. Extrinsic signals determine myeloid-erythroid lineage switch in MN1 leukemia. Exp Hematol 38: 174-179, 2010. View Abstract

Argiropoulos B, Yung E, Xiang P, Lo CY,  Kuchenbauer F, Palmqvist L, Reindl C, Heuser M, Sekulovic S, Rosten P, Muranyi A, Goh S-L, Featherstone M & Humphries RK. Linkage of the potent leukemogenic activity of Meis1 to cell cycle entry and transcriptional regulation of cyclin D3. Blood 115: 4071-82, 2010. View Abstract

Kuchenbauer F. Epigenomics, microRNAs and leukemias. Epigenomics 1: 219-222, 2009. View Abstract

Heuser M, Sly L, Argiropoulos B,  Kuchenbauer F, Lai C, Weng A, Leung M, Lin G, Brookes C, Fung S, Valk PJ, Delwel R, Lowenberg B, Krystal G & Humphries RK. Modelling the functional heterogeneity of leukemia stem cells: Role of STAT5 in leukemia stem cell self-renewal. Blood 114: 3983-3993, 2009. View Abstract

Heuser M,  Kuchenbauer F, Argiropoulos B, Sekulovic S, Leung M, Stasiak M, Ganser A & Humphries RK. Priming reloaded? Blood 114: 925-926, 2009. View Abstract

Morin RD, O'Connor M, Griffith M,  Kuchenbauer F, Delaney A, Prabhu A-L, Zhao Y, McDonald H, Zeng T, Hirst M, Eaves C & Marra MA. Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells. Genome Res 18: 610-621, 2008. View Abstract

Kuchenbauer F, Morin RD, Argiropoulos B, Petriv OI, Griffith M, Heuser M, Yung E, Piper J, Delaney A, Prabhu AL, Zhao Y, McDonald H, Zeng T, Hirst M, Hansen CL, Marra MA, Humphries RK. In-depth characterization of the microRNA transcriptome in a leukemia progression model. Genome Res 18:1787-97, 2008. View Abstract

Argiropoulos B, Palmqvist L, Yung E,  Kuchenbauer F, Heuser M, Sly LM, Wan A, Krystal G & Humphries RK. Linkage of Meis1 leukemogenic activity to multiple downstream effectors including Trib2 and Ccl3. Exp Hematol 36: 845-859, 2008. View Abstract

Heuser M, Argiropoulos B,  Kuchenbauer F, Yung E, Piper J, Fung S, Schlenk RF, Dohner K, Hinrichsen T, Rudolph C, Schambach A, Baum C, Schlegelberger B, Dohner H, Ganser A & Humphries RK. MN1 overexpression induces acute myeloid leukemia in mice and predicts ATRA resistance in patients with AML. Blood 110: 1639-1647, 2007. View Abstract

Kuchenbauer F, Schnittger S, Look T, Gilliland G, Tenen D, Haferlach T, Hiddemann W, Buske C & Schoch C. Identification of additional cytogenetic and molecular genetic abnormalities in acute myeloid leukaemia with t(8;21)/AML1-ETO. Br J Haematol 134: 616-619, 2006. View Abstract

Deshpande AJ, Cusan M, Rawat VPS, Krause A, Reuter H, Quintanilla-Martinez L, Pott C,  Kuchenbauer F, Ahmed F, Lichter P, Kneba M, Hiddemann W, Humphries RK, Bohlander SK, Feuring-Buske M & Buske C. Acute myeloid leukemia is propagated by a leukemic stem cell with lymphoid characteristics in a mouse model of CALM/AF10-positive leukemia. Cancer Cell 10: 363-374, 2006. View Abstract

Paez-Pereda M,  Kuchenbauer F, Arzt E & Stalla GK. Regulation of pituitary hormones and cell proliferation by components of the extracellular matrix. Braz J Med Biol Res 38: 1487-1494, 2005. View Abstract

Kuchenbauer F, Schoch C, Kern W, Hiddemann W, Haferlach T & Schnittger S. Impact of FLT3 mutations and promyelocytic leukaemia-breakpoint on clinical characteristics and prognosis in acute promyelocytic leukaemia. Br J Haematol 130: 196-202, 2005. View Abstract

Kuchenbauer F, Schoch C, Holler E, Haferlach T, Hiddemann W & Schnittger S. A rare case of acute myeloid leukemia with a CHIC2-ETV6 fusiongen and multiple other molecular aberrations. Leukemia 19: 2366-2368, 2005. View Abstract

Kuchenbauer F, Ngo T, Muth A, Stotzer O & Hiller E. [29-year-old female patient with pneumonia and enlarged abdominal lymph nodes] [Article in German]. Internist (Berl) 46: 917 2005. View Abstract

Kuchenbauer F, Kern W, Schoch C, Kohlmann A, Hiddemann W, Haferlach T & Schnittger S. Detailed analysis of FLT3 expression levels in acute myeloid leukemia. Haematologica 90: 1617-1625, 2005. View Abstract

Kuchenbauer F, Feuring-Buske M & Buske C. AML1-ETO needs a partner: new insights into the pathogenesis of t(8;21) leukemia. Cell Cycle 4: 1716-1718, 2005. View Abstract

Kuchenbauer F, Strassburg CP, Vogel A, Hiddemann W & Beuers U. UGT1A7 polymorphisms, polycyclic aromatic hydrocarbons and the development of hepatocellular cancer. Hepatology 40: 1021 2004. View PubMed Link

Kuchenbauer F, Theodoropoulou M, Hopfner U, Stalla J, Renner U, Tonn JC, Low MJ, Arzt E, Stalla GK & Paez-Pereda M. Laminin inhibits lactotroph proliferation and is reduced in early prolactinoma development. Mol Cell Endocrinol 207: 13-20, 2003. View Abstract

Kuchenbauer F, Biberthaler P, Stoger H & Mutschler W. [Teutschlander disease. A rare benign differential diagnosis in proliferating space-occupying lesions of soft tissues][Article in German]. Unfallchirurg 105: 572-575, 2002. View Abstract

Kuchenbauer F, Hopfner U, Stalla J, Arzt E, Stalla GK & Paez-Pereda M. Extracellular matrix components regulate ACTH production and proliferation in corticotroph tumor cells. Mol Cell Endocrinol 175: 141-148, 2001.View Abstract

 

Leo Escano

Co-op Student

Dr. Arefeh Rouhi

PhD
Staff Scientist

Simon (Xufeng) Wang

BSc Honour Thesis student

Amy Yu

PMP
Research Projects Manager

Mansen Yu

Research Student

Seeking talented students, postdoctoral fellows, and lab staff

We are looking for outstanding, motivated graduate students as well as postdoctoral fellows (full time or part time) who share our passion for medicine/science and want to make a difference for patients´ lives.

Our research is mainly translational and focuses on immunotherapies such as allogenic stem cell transplantation for acute myeloid leukemia. We are driven to improve patients' lives by addressing clinical “every day” challenges with state of the art research including preclinical animal models. Our goal is to translate our research into clinically applicable therapies. Scientific focuses are hematopoietic stem cell transplantation, hematopoietic stem cells physiology and pathophysiology as well as innovative treatment for Multiple Myeloma.

Multiple positions are available, including research students or technicians.  Interested candidates should send a statement of research interest, curriculum vitae and contact details for 3 referees to Dr. Arefeh Rouhi (arouhi[@]bccrc.ca).