People

PDF/RA

Back

Dr Geraldine Aubert — PhD

Research Associate

Overview
Publications

Dr. Geraldine Aubert, PhD, is a Research Associate at the Terry Fox Laboratory, a department of the British Columbia Cancer Agency in Vancouver, Canada. She received her undergraduate degree in Applied Biology (Medical Biology and Biochemistry) from the ‘Université de Bourgogne’ in Dijon, France. She obtained a PhD in Hematology in 2004 from University College London (UCL and Royal Free Hospital, United Kingdom) under the supervision of Dr Paul Travers. Her graduate work focused on generating, testing and applying novel tools to monitor specific cellular immune responses following bone marrow transplantation. This work led to a better understanding and to the assessment and enhancement of immunity to specific viral and tumor antigens, which proved to be useful clinical biomarkers. Her most recent research interests, working with Dr Peter Lansdorp, are related to factors that regulate telomere length and to human disease that result from inherited mutations in genes that encode components of the telomerase enzyme complex.

  1. Aubert G, Strauss KA, Lansdorp PM & Rider NL. Defects in Lymphocyte Telomere Hemeostasis Contribute to Cellular Immune phenotype in Cartilage-Hair Hypoplasia. J Allergy Clin Immunol. in press
  2. Jenkinson EM, Rodero MP, Kasher PR, Uggenti C, Oojageer A, Goosey LC, Rose Y, Kershaw CJ, Urquhart JE, Williams SG, Bhaskar SS, O'Sullivan J, Baerlocher GM, Haubitz M, Aubert G, Barañano KW, Barnicoat AJ, Battini R, Berger A, Blair EM, Brunstrom-Hernandez JE, Buckard JA, Cassiman DM, Caumes R, Cordelli DM, De Waele LM, Fay AJ, Ferreira P, Fletcher NA, Fryer AE, Goel H, Hemingway CA, Henneke M, Hughes I, Jefferson RJ, Kumar R, Lagae L, Landrieu PG, Lourenço CM, Malpas TJ, Mehta SG, Metz I, Naidu S, Õunap K, Panzer A, Prabhakar P, Quaghebeur G, Schiffmann R, Sherr EH, Sinnathuray KR, Soh C, Stewart HS, Stone J, Van Esch H, Van Mol CE, Vanderver A, Wakeling EL, Whitney A, Pavitt GD, Griffiths-Jones S, Rice GI, Revy P, van der Knaap MS, Livingston JH, O'Keefe RT, Crow YJ. Mutations in SNORD118 cause the cerebral microangiopathy leukoencephalopathy with calcifications and cysts. Nat Genet 48: 1185-92, 2016. View abstract 
  3. Abraham RS & Aubert G. Flow Cytometry: A Versatile Tool for Diagnosis and Monitoring of Primary Immunodeficiencies (PIDs). Clin Vaccine Immunol 23: 254-71, 2016.  View Abstract
  4. Dijke IE, Hoeppli RE, Ellis T, Pearcey J, Huang Q, McMurchy AN, Boer K, Peeters AM, Aubert G, Larsen I, Ross DB, Rebeyka I, Campbell A, Baan CC, Levings MK, West LJ. Discarded Human Thymus Is a Novel Source of Stable and Long-Lived Therapeutic Regulatory T Cells. Am J Transplant 16: 58-71, 2015. View Abstract
  5. Aubert G. Telomere Dynamics and Aging. In:  Progress in Molecular Biology and Translational Science., Vol. 125, (ed. R Calado), Elsevier Inc., pp 89-111, 2014. View Abstract
  6. Tutelman PR, Aubert G, Milner RA, Dalal BI, Schultz KR, Deyell RJ. Paroxysmal nocturnal haemoglobinuria phenotype cells and leucocyte subset telomere length in childhood acquired aplastic anaemia. Br J Haematol 164: 717-21, 2014. View Abstract
  7. Kannan N, Huda N, Tu L, Droumeva R, Aubert G, Chavez E, Brinkman RR, Lansdorp P, Emerman J, Abe S, Eaves C, Gilley D. The luminal progenitor compartment of the normal human mammary gland constitutes a unique site of telomere dysfunction. Stem Cell Reports 1: 28-37, 2013. View Abstract
  8. Frumento G, Zheng Y, Aubert G, Raeiszadeh M, Lansdorp PM, Moss P, Lee SP, Chen FE. Cord blood T cells retain early differentiation phenotype suitable for immunotherapy after TCR gene transfer to confer EBV specificity. Am J Transplant 13: 45-55, 2013. View Abstract
  9. Aubert G*, Baerlocher GM*, Vulto I, Poon SS & Lansdorp PM (*these authors contributed equally to the work). Collapse of telomere homeostasis in hematopoietic stem cells caused by heterozygous mutations in telomerase genes. PLoS Genet 8: e1002696, 2012. View Abstract
  10. Kent DG, Lin JC & Aubert G. The First AACR Special Conference on Stem Cells, Development, and Cancer: Some of these cells are not like the others. Cancer Res 71(17):5616-20, 2011. View Paper
  11. Aubert G. Short telomeres in hematopoietic disorders. Invited mini-review. The Microenvironment. (Canadian Hematology Society newsletter).  July 2011. View Article
  12. Aubert G*, Hills M* & Lansdorp PM (*these authors contributed equally to the work). Telomere Length Measurement - caveats and a critical assessment of the available technologies and tools. Invited review (peer reviewed), Mutation Research Reviews special issue on Telomeres and disease. Epub ahead of print, June 2011. View Paper
  13. Rusakiewicz S, Aubert G, Clarke RE, Travers PJ, Madrigal A & Dodi AI. Soluble HLA/peptide monomers cross-linked with co-stimulatory antibodies onto a streptavidin core molecule efficiently stimulate Antigen-specific T cell responses. Cancer Immunology Immunotherapy 58:1459-70, 2009. View Abstract
  14. Savage SA, Dokal I, Armanios M, Aubert G, Cowen EW, Domingo DL, Giri N, Greene MH, Orchard PJ, Tolar J, Tsilou E, Van Waes C, Wong JMY, Young NS, Alter BP. Dyskeratosis Congenita: The First NIH Clinical Research Workshop. Pediatric Blood & Cancer 53:520-3, 2009. View Paper
  15. Aubert G & Lansdorp PM. Telomeres and aging. Physiol Rev. 2008 Apr;88(2):557-79. Review. Citations: 114. View Paper
  16. Goldman FD*, Aubert G*, Klingelhutz AJ, Hills M, Cooper SR, Hamilton WS, Schlueter AJ, Lambie K, Eaves CJ & Lansdorp PM (*these authors contributed equally to the work). Characterization of primitive hematopoietic cells from patients with dyskeratosis congenita. Blood 111:4523-31, 2008. Citations: 14. View Paper
  17. Shepherd BE, Kiem HP, Lansdorp PM, Dunbar CE, Aubert G, LaRochelle A, Seggewiss R, Guttorp P & Abkowitz JL. Hematopoietic stem-cell behavior in nonhuman primates. Blood 110:1806-13, 2007. View Paper
  18. Ouyang Q, Wagner WM, Walter S, Muller CA, Wikby A, Aubert G, Klatt T, Stevanovic S, Dodi T, & Pawelec G. An age-related increase in the number of CD8+ T cells carrying receptors for an immunodominant Epstein-Barr virus (EBV) epitope is counteracted by a decreased frequency of their antigen-specific responsiveness. Mech Ageing Dev 124:477-485, 2003. View Abstract
  19. Ouyang Q, Wagner WM, Wikby A, Walter S, Aubert G, Dodi AI, Travers P, & Pawelec G. Large numbers of dysfunctional CD8+ T lymphocytes bearing receptors for a single dominant CMV epitope in the very old. J Clin Immunol 23:247-257, 2003. View Abstract
  20. Chen FE, Aubert G, Travers P, Dodi IA & Madrigal A. HLA tetramers and anti-CMV immune responses: from epitope to immunotherapy. Cytotherapy 4:41-48, 2002. View Abstract
  21. Szmania S, Galloway A, Bruorton M, Musk P, Aubert G, Arthur A, Pyle H, Hensel N, Ta N, Lamb L, Jr, Dodi T, Madrigal A, Barrett J, Henslee-Downey J & van Rhee F. Isolation and expansion of cytomegalovrius-specific cytotoxic T lymphocytes to clinical scale from a single blood draw using dendritic cells and HLA-tetramers. Blood 98:505-512, 2001. Citations: 103. View Paper
  22. Clark RE, Dodi IA, Hill SC, Lill JR, Aubert G, Macintyre AR, Rojas J, Bourdon A, Bonner PL, Wang L, Christmas SE, Travers PJ, Craser CS, Rees RC & Madrigal JA. Direct evidence that leukemic cells present HLA-associated immunogenic peptides derived from the BCR-ABLb3a2 fusion protein. Blood 98:2887-2893, 2001. Citations: 156. View Paper
  23. Aubert G, Hassan-Walker AF, Madrigal JA, Emery VC, Morte C, Grace S, Koh MB, Potter M, Prentice HG, Dodi IA & Travers PJ. Cytomegalovirus-specific cellular immune responses and viremia in recipients of allogeneic stem cell transplants. J Infect Dis 184:955-963, 2001. Citations: 70.  View Paper