Principal Investigators


Dr. Richard Keith Humphries — MD, PhD, FRS(C)

Distinguished Scientist Emeritus

Research Interest
Lab Members

Current Appointments


  • Fellow of the Royal Society of Canada
  • Terry Fox Award British Columbia Medical Association
  • Killam Research Prize, UBC
  • Distinguished Emeritus Member, American Society of Hematology
  • Emeritus Member, International Society of Experimental Hematology
  • Board Member and  Chair Medical Scientific Committee, Leukemia and Lymphoma Society of Canada

Major Research Interests

  • Normal Hematopoietic Stem Cells – the genes and processes controlling key properties of self-renewal
  • Acute Myeloid Leukemia – the genes and processes underlying transformation of normal blood cells to leukemic growth
  • Gene therapy by targeting hematopoietic stem cells with special emphasis on hemoglobinopathies (Thalassemia and Sickle Cell Disease)

Key Experimental Approaches

  • Genetic modification of normal and leukemic cells using lentiviral/retroviral gene transfer
  • Genetic modeling of leukemia using murine and human blood cells
  • Crispr/Cas9 gene editing to create new murine models to study key hematopoietic regulatory genes
  • Study of the role of key transcription factors (e.g. Hox, Hox co-factors such as Meis1, MN1) in normal and leukemic hematopoiesis.


As a Distinguished Scientist Emeritus of BC Cancer and Professor Emeritus of Hematology, UBC, I am no longer taking on graduate students or postdoctoral fellows.  I do however serve by invitation on supervisory committees and actively participate in ongoing research programs such as the the Terry Fox New Frontier Program Project in Exploiting Pathogenic Mechanisms in Acute Leukemia for Clinical Translation and mentorship of junior faculty.

Amy Yu

Senior Research Projects Manager