Selected Publications

 2010

Reiss D, Zhang Y, Rouhi A, Reuter M & Mager DL. Variable DNA methylation of transposable elements: the case study of mouse early transposons.  Epigenetics 5: 1-12, 2010. View Abstract

Rogers SL, Zhao Y, Jiang X, Eaves CJ, Mager DL & Rouhi A. Expression of the leukemic prognostic marker CD7 is linked to epigenetic modifications in chronic myeloid leukemia.  Mol Cancer 9:41 2010. View Abstract

Romanish MT, Cohen CJ & Mager DL. Potential mechanisms of endogenous retroviral-mediated genomic instability in human cancer.  Semin Cancer Biol Epub ahead of print. View Abstract

 2009

Rouhi A, Lai CB, Cheng TP, Takei F, Yokoyama WM & Mager DL. Evidence for high bi-allelic expression of activating Ly49 receptors.  Nucleic Acids Res  37: 5331-5342, 2009. View Abstract

Cohen C, Lock W & Mager DL. Endogenous retroviral LTRs as promoters for human genes: a critical assessment.  Gene  448: 105-114, 2009. View Abstract

Hotta A, Cheung AYL, Farra N, Vijayaragavan K, Seguin CA, Draper JS, Pasceri P, Maksakova IA, Mager DL, Rossant J, Bhatia M & Ellis J. Isolation of human iPS cells using EOS lentiviral vectors to select for pluripotency.  Nat Methods 6: 370-376, 2009. View Abstract

Romanish MT, Nakamura H, Lai CB, Wang Y & Mager DL. A novel protein isoform of the multicopy human NAIP gene derives from intragenic Alu SINE promoters.  PLoS One 4: e5761, 2009.  View Abstract

Lai CB, Zhang Y, Rogers SL & Mager DL. Creation of the two isoforms of rodent NKG2D was driven by a B1 retrotransposon insertion.  Nucleic Acids Res  37: 3032-3043, 2009. View Abstract

Maksakova IA, Zhang Y, van de Lagemaat LN & Mager DL. Preferential epigenetic suppression of the autonomous MusD over the non-autonomous ETn mouse retrotransposons.  Mol Cell Biol 29: 2456-2468, 2009.  View Abstract

2008

Dong KB, Maksakova IA, Mohn F, Leung D, Appanah R, Lee S, Yang HW, Lam LL, Mager DL, Schubeler D, Tachibana M, Shinkai Y & Lorincz MC. DNA methylation in ES cells requires the lysine methyltransferase G9a but not its catalytic activity.  EMBO J 27: 2691-2701, 2008. View Abstract

 Maksakova IA, Mager DL & Reiss D. Keeping active endogenous retroviral elements in check: the epigenetic perspective.  Cell Mol Life Sci 65 (Suppl. Endogenous Retroviruses): 3329-3347, 2008. View Abstract

Rouhi A, Mager DL, Humphries RK & Kuchenbauer F. MiRNAs, epigenetics and cancer.  Mamm Genome  19: 517-525, 2008.  View Abstract

Zhang Y, Maksakova IA, Gagnier L, van de Lagemaat LN & Mager DL. Genome-wide assessments reveal extremely high levels of polymorphism of two active families of mouse endogenous retroviral elements.  PLoS Genet 4:e1000007, 2008. View Abstract

2007

Reiss D, Zhang Y, & Mager DL. Widely variable endogenous retroviral methylation levels in human placenta. Nucleic Acids Res 35 (14): 4743-54, 2007. View Abstract

Wilson EB, Parachoniak CA, Carpenito C, Mager DL, & Takei F. Expression of murine killer immunoglobulin-like receptor KIRL1 on CD1d-independent NK1.1(+) T cells. Immunogenetics 59 (8): 641-51, 2007. View Abstract

Romanish MT, Lock WM, van de Lagemaat LN, Dunn CA, & Mager DL. Repeated recruitment of LTR retrotransposons as promoters by the anti-apoptotic locus NAIP during mammalian evolution. PLoS Genet 3 (1): e10, 2007. View Abstract

Reiss D, & Mager DL. Stochastic epigenetic silencing of retrotransposons: does stability come with age? Gene 390 (1-2): 130-5, 2007. View Abstract

Rouhi A, Brooks CG, Takei F, & Mager DL. Plasticity of Ly49g expression is due to epigenetics. Mol Immunol 44 (5): 821-6, 2007. View Abstract

2006

van de Lagemaat LN, Medstrand P, & Mager DL. Multiple effects govern endogenous retrovirus survival patterns in human gene introns. Genome Biol 7 (9): R86, 2006. View Abstract

Gerlo S, Davis JR, Mager DL, & Kooijman R. Prolactin in man: a tale of two promoters. Bioessays 28 (10): 1051-5, 2006. View Abstract

Rogers SL, Rouhi A, Takei F, & Mager DL. A role for DNA hypomethylation and histone acetylation in maintaining allele-specific expression of mouse NKG2A in developing and mature NK cells. J Immunol 177 (1): 414-21, 2006. View Abstract

Rouhi A, Gagnier L, Takei F, & Mager DL. Evidence for epigenetic maintenance of Ly49a monoallelic gene expression. J Immunol 176 (5): 2991-9, 2006. View Abstract

Maksakova IA, Romanish MT, Gagnier L, Dunn CA, van de Lagemaat LN, & Mager DL. Retroviral elements and their hosts: insertional mutagenesis in the mouse germ line. PLoS Genet 2 (1): e2, 2006. View Abstract

Dunn CA, Romanish MT, Gutierrez LE, van de Lagemaat LN, & Mager DL. Transcription of two human genes from a bidirectional endogenous retrovirus promoter. Gene 366 (2): 335-42, 2006. View Abstract

2005

Maksakova IA, & Mager DL. Transcriptional regulation of early transposon elements, an active family of mouse long terminal repeat retrotransposons. J Virol 79 (22): 13865-74, 2005. View Abstract

van de Lagemaat LN, Gagnier L, Medstrand P, & Mager DL. Genomic deletions and precise removal of transposable elements mediated by short identical DNA segments in primates. Genome Res 15 (9): 1243-9, 2005. View Abstract

Dunn CA, van de Lagemaat LN, Baillie GJ, & Mager DL. Endogenous retrovirus long terminal repeats as ready-to-use mobile promoters: the case of primate beta3GAL-T5. Gene 364: 2-12, 2005. View Abstract

Medstrand P, van de Lagemaat LN, Dunn CA, Landry JR, Svenback D, & Mager DL. Impact of transposable elements on the evolution of mammalian gene regulation. Cytogenet Genome Res 110 (1-4): 342-52, 2005. View Abstract

Dunn CA, & Mager DL. Transcription of the human and rodent SPAM1 / PH-20 genes initiates within an ancient endogenous retrovirus. BMC Genomics 6 (1): 47, 2005. View Abstract

2004

Wilhelm BT, & Mager DL. Rapid expansion of the Ly49 gene cluster in rat. Genomics 84 (1): 218-21, 2004. View Abstract

Baillie GJ, van de Lagemaat LN, Baust C, & Mager DL. Multiple groups of endogenous betaretroviruses in mice, rats, and other mammals. J Virol 78 (11): 5784-98, 2004. View Abstract

2003

Mager DL & Medstrand P. Retroviral repeat sequences. In:  Nature Encyclopedia of the Human Genome., Vol. 5, Nature Publishing Group, pp 57-63, 2003.

Landry JR, Mager DL, & Wilhelm BT. Complex controls: the role of alternative promoters in mammalian genomes. Trends Genet 19 (11): 640-8, 2003. View Abstract

Baust C, Gagnier L, Baillie GJ, Harris MJ, Juriloff DM, & Mager DL. Structure and expression of mobile ETnII retroelements and their coding-competent MusD relatives in the mouse. J Virol 77 (21): 11448-58, 2003. View Abstract

van de Lagemaat LN, Landry JR, Mager DL, & Medstrand P. Transposable elements in mammals promote regulatory variation and diversification of genes with specialized functions. Trends Genet 19 (10): 530-6, 2003. View Abstract

Dunn CA, Medstrand P, & Mager DL. An endogenous retroviral long terminal repeat is the dominant promoter for human beta1,3-galactosyltransferase 5 in the colon. Proc Natl Acad Sci U S A 100 (22): 12841-6, 2003. View Abstract

Wilhelm BT, Landry JR, Takei F, & Mager DL. Transcriptional control of murine CD94 gene: differential usage of dual promoters by lymphoid cell types. J Immunol 171 (8): 4219-26, 2003. View Abstract

Landry JR, & Mager DL. Functional analysis of the endogenous retroviral promoter of the human endothelin B receptor gene. J Virol 77 (13): 7459-66, 2003. View Abstract

Wilhelm BT, & Mager DL. Identification of a new murine lectin-like gene in close proximity to CD94. Immunogenetics 55 (1): 53-6, 2003. View Abstract

Gagnier L, Wilhelm BT, & Mager DL. Ly49 genes in non-rodent mammals. Immunogenetics 55 (2): 109-15, 2003. View Abstract

Wilhelm BT, Gagnier L, & Mager DL. Sequence analysis of the ly49 cluster in C57BL/6 mice: a rapidly evolving multigene family in the immune system. Genomics 80 (6): 646-61, 2002. View Abstract

2002

Landry JR, Rouhi A, Medstrand P, & Mager DL. The Opitz syndrome gene Mid1 is transcribed from a human endogenous retroviral promoter. Mol Biol Evol 19 (11): 1934-42, 2002. View Abstract

Landry JR, & Mager DL. Widely spaced alternative promoters, conserved between human and rodent, control expression of the Opitz syndrome gene MID1. Genomics 80 (5): 499-508, 2002. View Abstract

Medstrand P, van de Lagemaat LN, & Mager DL. Retroelement distributions in the human genome: variations associated with age and proximity to genes. Genome Res 12 (10): 1483-95, 2002. View Abstract

Baust C, Baillie GJ, & Mager DL. Insertional polymorphisms of ETn retrotransposons include a disruption of the wiz gene in C57BL/6 mice. Mamm Genome 13 (8): 423-8, 2002. View Abstract

McQueen KL, Wilhelm BT, Harden KD, & Mager DL. Evolution of NK receptors: a single Ly49 and multiple KIR genes in the cow. Eur J Immunol 32 (3): 810-7, 2002. View Abstract

2001

Landry JR, Medstrand P, & Mager DL. Repetitive elements in the 5’ untranslated region of a human zinc-finger gene modulate transcription and translation efficiency. Genomics 76 (1-3): 110-6, 2001. View Abstract

Takei F, McQueen KL, Maeda M, Wilhelm BT, Lohwasser S, Lian RH, & Mager DL. Ly49 and CD94/NKG2: developmentally regulated expression and evolution. Immunol Rev 181: 90-103, 2001. View Abstract

Wilhelm BT, McQueen KL, Freeman JD, Takei F, & Mager DL. Comparative analysis of the promoter regions and transcriptional start sites of mouse Ly49 genes. Immunogenetics 53 (3): 215-24, 2001. View Abstract

Mager DL, McQueen KL, Wee V, & Freeman JD. Evolution of natural killer cell receptors: coexistence of functional Ly49 and KIR genes in baboons. Curr Biol 11 (8): 626-30, 2001. View Abstract

McQueen KL, Wilhelm BT, Takei F, & Mager DL. Functional analysis of 5’ and 3’ regions of the closely related Ly49c and j genes. Immunogenetics 52 (3-4): 212-23, 2001. View Abstract

Medstrand P, Landry JR, & Mager DL. Long terminal repeats are used as alternative promoters for the endothelin B receptor and apolipoprotein C-I genes in humans. J Biol Chem 276 (3): 1896-903, 2001. View Abstract

2000

Mager DL, & Freeman JD. Novel mouse type D endogenous proviruses and ETn elements share long terminal repeat and internal sequences. J Virol 74 (16): 7221-9, 2000. View Abstract

1999

Mager DL, Hunter DG, Schertzer M, & Freeman JD. Endogenous retroviruses provide the primary polyadenylation signal for two new human genes (HHLA2 and HHLA3). Genomics 59 (3): 255-63, 1999. View Abstract

McQueen KL, Lohwasser S, Takei F, & Mager DL. Expression analysis of new Ly49 genes: most transcripts of Ly49j lack the transmembrane domain. Immunogenetics 49 (7-8): 685-91, 1999. View Abstract

Kowalski PE, Freeman JD, & Mager DL. Intergenic splicing between a HERV-H endogenous retrovirus and two adjacent human genes. Genomics 57 (3): 371-9, 1999. View Abstract

1998

Medstrand P, & Mager DL. Human-specific integrations of the HERV-K endogenous retrovirus family. J Virol 72 (12): 9782-7, 1998. View Abstract

McQueen KL, Freeman JD, Takei F, & Mager DL. Localization of five new Ly49 genes, including three closely related to Ly49c. Immunogenetics 48 (3): 174-83, 1998. View Abstract

Kowalski PE, & Mager DL. A human endogenous retrovirus suppresses translation of an associated fusion transcript, PLA2L. J Virol 72 (7): 6164-8, 1998. View Abstract

1997

Takei F, Brennan J, & Mager DL. The Ly-49 family: genes, proteins and recognition of class I MHC. Immunol Rev 155: 67-77, 1997. View Abstract

1996

Brennan J, Lemieux S, Freeman JD, Mager DL, & Takei F. Heterogeneity among Ly-49C natural killer (NK) cells: characterization of highly related receptors with differing functions and expression patterns. J Exp Med 184 (6): 2085-90, 1996. View Abstract