PUBLICATIONS

Wederell ED, Bilenky M , Cullum R, Thiessen N, Dagpinar M, Delaney A, Varhol R, Zhao YJ, Zeng T, Bernier B, Ingham M, Hirst M, Robertson G Marra MA, Jones S, Hoodless PA. Global Analysis of In Vivo FoxA2 Binding Sites in Mouse Adult Liver Using Massively Parallel Sequencing.  Nuc Acids Res 36: 4549-4564, 2008. View Abstract

Robertson AG, Bilenky M, Tam A, Zhao Y, Zeng T, Thiessen N, Cezard T, Fejes A, Wederell E, Cullum R, Euskirchen G, Krzywinski M, Birol I, Snyder M, Hoodless PA, Hirst M, Marra MA, Jones SJM.  Genome wide relationship between histone H3 lysine 4 mono-and-tri methylation and transcription factor binding.  Genome Res 18:1906-1917, 2008 View Abstract

Niessen K, Fu YX, Chang L, Wong F, McFadden D, Hoodless PA & Karsan A. Slug is a direct Notch target required for initiation of cardiac cushion cellularization.  J Cell Biol 182:315-25, 2008.  View Abstract

Hoffman BG, Zavaglia B, Witzsche J, Ruiz de Algara T, Beach M, Hoodless PA, Jones SJ, Marra MA, & Helgason CD. Identification of transcripts with enriched expression in the developing and adult pancreas. Genome Biol 9 (6): R99, 2008. View Article

Bowie MB, Kent DG, Dykstra B, McKnight KD, McCaffrey L, Hoodless PA, & Eaves CJ. Identification of a new intrinsically timed developmental checkpoint that reprograms key hematopoietic stem cell properties. Proc Natl Acad Sci U S A 104 (14): 5878-82, 2007. View Abstract

Hou J, Charters AM, Lee SC, Zhao Y, Wu MK, Jones SJ, Marra MA, & Hoodless PA. A systematic screen for genes expressed in definitive endoderm by Serial Analysis of Gene Expression (SAGE). BMC Dev Biol 7: 92, 2007. View Abstract

Khattra J, Delaney AD, Zhao Y, Siddiqui A, Asano J, McDonald H, Pandoh P, Dhalla N, Prabhu AL, Ma K, Lee S, Ally A, Tam A, Sa D, Rogers S, Charest D, Stott J, Zuyderduyn S, Varhol R, Eaves C, Jones S, Holt R, Hirst M, Hoodless PA, & Marra MA. Large-scale production of SAGE libraries from microdissected tissues, flow-sorted cells, and cell lines. Genome Res 17 (1): 108-16, 2007. View Abstract

McKnight KD, Hou J, & Hoodless PA. Dynamic expression of thyrotropin-releasing hormone in the mouse definitive endoderm. Dev Dyn 236 (10): 2909-17, 2007. View Abstract

Noorali S, Kurita T, Woolcock B, de Algara TR, Lo M, Paralkar V, Hoodless P, & Vielkind J. Dynamics of expression of growth differentiation factor 15 in normal and PIN development in the mouse. Differentiation 75 (4): 325-36, 2007. View Abstract

Bowie MB, McKnight KD, Kent DG, McCaffrey L, Hoodless PA, & Eaves CJ. Hematopoietic stem cells proliferate until after birth and show a reversible phase-specific engraftment defect. J Clin Invest 116 (10): 2808-16, 2006. View Abstract

Houde C, Dickinson RJ, Houtzager VM, Cullum R, Montpetit R, Metzler M, Simpson EM, Roy S, Hayden MR, Hoodless PA, & Nicholson DW. Hippi is essential for node cilia assembly and Sonic hedgehog signaling. Dev Biol 300 (2): 523-33, 2006. View Abstract

Mar L, & Hoodless PA. Embryonic fibroblasts from mice lacking Tgif were defective in  cell cycling. Mol Cell Biol 26 (11): 4302-10, 2006. View Abstract

Siddiqui AS, Khattra J, Delaney AD, Zhao Y, Astell C, Asano J, Babakaiff R, Barber S, Beland J, Bohacec S, Brown-John M, Chand S, Charest D, Charters AM, Cullum R, Dhalla N, Featherstone R, Gerhard DS, Hoffman B, Holt RA, Hou J, Kuo BY, Lee LL, Lee S, Leung D, Ma K, Matsuo C, Mayo M, McDonald H, Prabhu AL, Pandoh P, Riggins GJ, de Algara TR, Rupert JL, Smailus D, Stott J, Tsai M, Varhol R, Vrljicak P, Wong D, Wu MK, Xie YY, Yang G, Zhang I, Hirst M, Jones SJ, Helgason CD, Simpson EM, Hoodless PA, & Marra MA. A mouse atlas of gene expression: large-scale digital gene-expression profiles from precisely defined developing C57BL/6J mouse tissues and cells. Proc Natl Acad Sci U S A 102 (51): 18485-90, 2005. View Abstract

Noseda M, McLean G, Niessen K, Chang L, Pollet I, Montpetit R, Shahidi R, Dorovini-Zis K, Li L, Beckstead B, Durand RE, Hoodless PA, & Karsan A. Notch activation results in phenotypic and functional changes consistent with endothelial-to-mesenchymal transformation. Circ Res 94 (7): 910-7, 2004. View Abstract

Hoodless PA, Pye M, Chazaud C, Labbe E, Attisano L, Rossant J, & Wrana JL. FoxH1 (Fast) functions to specify the anterior primitive streak in the mouse. Genes Dev 15 (10): 1257-71, 2001. View Abstract

Sirard C, Kim S, Mirtsos C, Tadich P, Hoodless PA, Itie A, Maxson R, Wrana JL, & Mak TW. Targeted disruption in murine cells reveals variable requirement for Smad4 in transforming growth factor beta-related signaling. J Biol Chem 275 (3): 2063-70, 2000. View Abstract

Tremblay KD, Hoodless PA, Bikoff EK, & Robertson EJ. Formation of the definitive endoderm in mouse is a Smad2-dependent process. Development 127 (14): 3079-90, 2000. View Abstract

Hoodless PA, Tsukazaki T, Nishimatsu S, Attisano L, Wrana JL, & Thomsen GH. Dominant-negative Smad2 mutants inhibit activin/Vg1 signaling and disrupt axis formation in Xenopus. Dev Biol 207 (2): 364-79, 1999. View Abstract

Hoodless PA, & Wrana JL. Mechanism and function of signaling by the TGF beta superfamily. Curr Top Microbiol Immunol 228: 235-72, 1998. View Abstract

Labbe E, Silvestri C, Hoodless PA, Wrana JL, & Attisano L. Smad2 and Smad3 positively and negatively regulate TGF beta-dependent transcription through the forkhead DNA-binding protein FAST2. Mol Cell 2 (1): 109-20, 1998. View Abstract

Macias-Silva M, Hoodless PA, Tang SJ, Buchwald M, & Wrana JL. Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2. J Biol Chem 273 (40): 25628-36, 1998. View Abstract

Tang SJ, Hoodless PA, Lu Z, Breitman ML, McInnes RR, Wrana JL, & Buchwald M. The Tlx-2 homeobox gene is a downstream target of BMP signalling and is required for mouse mesoderm development. Development 125 (10): 1877-87, 1998. View Abstract

Waldrip WR, Bikoff EK, Hoodless PA, Wrana JL, & Robertson EJ. Smad2 signaling in extraembryonic tissues determines anterior-posterior polarity of the early mouse embryo. Cell 92 (6): 797-808, 1998. View Abstract

Li M, Li J, Hoodless PA, Tzukazaki T, Wrana JL, Attisano L, & Tsang BK. Mothers against decapentaplegic-related protein 2 expression in avian granulosa cells is up-regulated by transforming growth factor beta during ovarian follicular development. Endocrinology 138 (9): 3659-65, 1997. View Abstract

Eppert K, Scherer SW, Ozcelik H, Pirone R, Hoodless P, Kim H, Tsui LC, Bapat B, Gallinger S, Andrulis IL, Thomsen GH, Wrana JL, & Attisano L. MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma. Cell 86 (4): 543-52, 1996. View Abstract

Hoodless PA, Haerry T, Abdollah S, Stapleton M, O’Connor MB, Attisano L, & Wrana JL. MADR1, a MAD-related protein that functions in BMP2 signaling pathways. Cell 85 (4): 489-500, 1996. View Abstract

Macias-Silva M, Abdollah S, Hoodless PA, Pirone R, Attisano L, & Wrana JL. MADR2 is a substrate of the TGFbeta receptor  and its phosphorylation is required for nuclear accumulation and signaling. Cell 87 (7): 1215-24, 1996. View Abstract

Duncan SA, Manova K, Chen WS, Hoodless P, Weinstein DC, Bachvarova RF, & Darnell JE, Jr. Expression of transcription factor HNF-4 in the extraembryonic endoderm, gut, and nephrogenic tissue of the developing mouse embryo: HNF-4 is a marker for primary endoderm in the implanting blastocyst. Proc Natl Acad Sci U S A 91 (16): 7598-602, 1994. View Abstract

Weinstein DC, Ruiz i Altaba A, Chen WS, Hoodless P, Prezioso VR, Jessell TM, & Darnell JE, Jr. The winged-helix transcription factor HNF-3 beta is required for notochord development in the mouse embryo. Cell 78 (4): 575-88, 1994. View Abstract

Hoodless PA, Ryan AK, Schrader TJ, & Deeley RG. Characterization of liver-enriched proteins binding to a developmentally demethylated site flanking the avian apoVLDLII gene. DNA Cell Biol 11 (10): 755-65, 1992. View Abstract

Hoodless PA, Roy RN, Ryan AK, Hache RJ, Vasa MZ, & Deeley RG. Developmental regulation of specific protein interactions with an enhancerlike binding site far upstream from the avian very-low-density apolipoprotein II gene. Mol Cell Biol 10 (1): 154-64, 1990. View Abstract