Medyouf H, Gao
XH, Armstrong F, Gusscott S, Liu Q, Gedman AL, Matherly LH, Schultz
KR, Pflumio F, You MJ & Weng
AP. Acute T-cell leukemias remain dependent on notch signaling
despite PTEN and INK4A/ARF loss.
Blood 2010 (Epub ahead of print).
View Abstract
Hahne F*,
Khodabakhshi AH*, Bashashati A, Wong C-J, Gascoyne RD,
Weng AP, Seifert-Margolis
S, Bourcier K, Asare A, Lumley T, Gentleman R & Brinkman RR.
Per-channel basis normalization methods for flow cytometry data.
Cytometry A 77: 121-31, 2010.
View Abstract
Heuser M, Sly
LM, Argiropoulos B, Kuchenbauer F, Lai C, Weng A, Leung M, Lin G,
Brookes C, Fung S, Valk PJ, Delvel R, Lowenberg B, Krystal G &
Humphries
RK. Modeling the functional heterogeneity of leukemia stem cells:
Role of STAT5 in leukemia stem cell self-renewal. Blood,
114:3983-3993, 2009.
View Abstract
Johnson NA, Boyle M, Bashashati A, Leach S, Brooks-Wilson A, Sehn
LH, Chhanabhai M, Brinkman RR, Connors JM,
Weng AP & Gascoyne RD. Diffuse large B cell
lymphoma: reduced CD20 expression is associated with an inferior
survival. Blood 113: 3773-80, 2009.
View Abstract
Chan SM,
Weng AP, Tibshirani R, Aster JC, & Utz PJ. Notch
signals positively regulate activity of the mTOR pathway in T-cell
acute lymphoblastic leukemia. Blood 110 (1): 278-86, 2007.
View Abstract
Rodig SJ, Savage KJ, LaCasce AS,
Weng AP, Harris NL, Shipp MA, Hsi ED, Gascoyne RD, &
Kutok JL. Expression of TRAF1 and nuclear c-Rel distinguishes
primary mediastinal large cell lymphoma from other types of diffuse
large B-cell lymphoma. Am J Surg Pathol 31 (1): 106-12, 2007.
View Abstract
Palomero T, Lim WK, Odom DT, Sulis ML, Real PJ, Margolin A, Barnes
KC, O’Neil J, Neuberg D,
Weng AP, Aster JC, Sigaux F, Soulier J, Look AT,
Young RA, Califano A, & Ferrando AA. NOTCH1 directly regulates c-MYC
and activates a feed-forward-loop transcriptional network promoting
leukemic cell growth. Proc Natl Acad Sci U S A 103 (48): 18261-6,
2006.
View Abstract
Weng AP, Millholland JM, Yashiro-Ohtani
Y, Arcangeli ML, Lau A, Wai C, Del Bianco C, Rodriguez CG, Sai H,
Tobias J, Li Y, Wolfe MS, Shachaf C, Felsher D, Blacklow SC, Pear
WS, & Aster JC. c-Myc is an important direct target of Notch1 in
T-cell acute lymphoblastic leukemia/lymphoma. Genes Dev 20 (15):
2096-109, 2006.
View Abstract
Ringrose A, Zhou Y, Pang E, Zhou L, Lin AE, Sheng G, Li XJ,
Weng A, Su MW, Pittelkow MR, & Jiang X. Evidence for
an oncogenic role of AHI-1 in Sezary syndrome, a leukemic variant of
human cutaneous T-cell lymphomas. Leukemia 20 (9): 1593-601, 2006.
View Abstract
Weng AP, & Lau A. Notch signaling
in T-cell acute lymphoblastic leukemia. Future Oncol 1 (4): 511-9,
2005.
View Abstract
Sanchez-Irizarry C, Carpenter AC,
Weng AP, Pear WS, Aster JC, & Blacklow SC. Notch
subunit heterodimerization and prevention of ligand-independent
proteolytic activation depend, respectively, on a novel domain and
the LNR repeats. Mol Cell Biol 24 (21): 9265-73, 2004.
View Abstract
Weng AP, Ferrando AA, Lee W,
Morris JPt, Silverman LB, Sanchez-Irizarry C, Blacklow SC, Look AT,
& Aster JC. Activating mutations of NOTCH1 in human T cell acute
lymphoblastic leukemia. Science 306 (5694): 269-71, 2004.
View Abstract
Maillard I,
Weng AP, Carpenter AC, Rodriguez CG, Sai H, Xu L,
Allman D, Aster JC, & Pear WS. Mastermind critically regulates
Notch-mediated lymphoid cell fate decisions. Blood 104 (6):
1696-702, 2004.
View Abstract
Lacasce A, Howard O, Lib S, Fisher D,
Weng A, Neuberg D, & Shipp M. Modified magrath
regimens for adults with Burkitt and Burkitt-like lymphomas:
preserved efficacy with decreased toxicity. Leuk Lymphoma 45 (4):
761-7, 2004.
View Abstract
Brown JR,
Weng AP, & Freedman AS. Hodgkin disease associated
with T-cell non-Hodgkin lymphomas: case reports and review of the
literature. Am J Clin Pathol 121 (5): 701-8, 2004.
View Abstract
Das I, Craig C, Funahashi Y, Jung KM, Kim TW, Byers R,
Weng AP, Kutok JL, Aster JC, & Kitajewski J. Notch
oncoproteins depend on gamma-secretase/presenilin activity for
processing and function. J Biol Chem 279 (29): 30771-80, 2004.
View Abstract
Weng AP, & Aster JC. Multiple
niches for Notch in cancer: context is everything. Curr Opin Genet
Dev 14 (1): 48-54, 2004.
View Abstract
Weng AP, & Aster JC. No T without
D3: a critical role for cyclin D3 in normal and malignant precursor
T cells. Cancer Cell 4 (6): 417-8, 2003.
View Abstract
Dorfman DM, van den Elzen P,
Weng AP, Shahsafaei A, & Glimcher LH. Differential
expression of T-bet, a T-box transcription factor required for Th1
T-cell development, in peripheral T-cell lymphomas. Am J Clin Pathol
120 (6): 866-73, 2003.
View Abstract
Weng AP, Shahsafaei A, & Dorfman
DM. CXCR4/CD184 immunoreactivity in T-cell non-Hodgkin lymphomas
with an overall Th1- Th2+ immunophenotype. Am J Clin Pathol 119 (3):
424-30, 2003.
View Abstract
Nam Y,
Weng AP, Aster JC, & Blacklow SC. Structural
requirements for assembly of the CSL.intracellular
Notch1.Mastermind-like 1 transcriptional activation complex. J Biol
Chem 278 (23): 21232-9, 2003.
View Abstract
Weng AP, Nam Y, Wolfe MS, Pear
WS, Griffin JD, Blacklow SC, & Aster JC. Growth suppression of pre-T
acute lymphoblastic leukemia cells by inhibition of notch signaling.
Mol Cell Biol 23 (2): 655-64, 2003.
View Abstract
Wohlschlegel JA, Kutok JL,
Weng AP, & Dutta A. Expression of geminin as a
marker of cell proliferation in normal tissues and malignancies. Am
J Pathol 161 (1): 267-73, 2002.
View Abstract
Gaudet G, Friedberg JW,
Weng A, Pinkus GS, & Freedman AS. Breast lymphoma
associated with breast implants: two case-reports and a review of
the literature. Leuk Lymphoma 43 (1): 115-9, 2002.
View Abstract
Izon DJ, Aster JC, He Y,
Weng A, Karnell FG, Patriub V, Xu L, Bakkour S,
Rodriguez C, Allman D, & Pear WS. Deltex1 redirects lymphoid
progenitors to the B cell lineage by antagonizing Notch1. Immunity
16 (2): 231-43, 2002.
View Abstract
Shipp MA, Ross KN, Tamayo P,
Weng AP, Kutok JL, Aguiar RC, Gaasenbeek M, Angelo
M, Reich M, Pinkus GS, Ray TS, Koval MA, Last KW, Norton A, Lister
TA, Mesirov J, Neuberg DS, Lander ES, Aster JC, & Golub TR. Diffuse
large B-cell lymphoma outcome prediction by gene-expression
profiling and supervised machine learning. Nat Med 8 (1): 68-74,
2002.
View Abstract
Weng A, Magnuson T, & Storb U.
Strain-specific transgene methylation occurs early in mouse
development and can be recapitulated in embryonic stem cells.
Development 121 (9): 2853-9, 1995.
View Abstract
Weng A, Engler P, & Storb U. The
bulk chromatin structure of a murine transgene does not vary with
its transcriptional or DNA methylation status. Mol Cell Biol 15 (1):
572-9, 1995.
View Abstract
Engler P,
Weng A, & Storb U. Influence of CpG methylation and
target spacing on V(D)J recombination in a transgenic substrate. Mol
Cell Biol 13 (1): 571-7, 1993.
View Abstract
Storb U, Engler P, Klotz E,
Weng A, Haasch D, Pinkert C, Doglio L, Glymour M, &
Brinster R. Rearrangement and expression of immunoglobulin genes in
transgenic mice. Curr Top Microbiol Immunol 182: 137-41, 1992.
View Abstract
Chensue SW, Shmyr-Forsch C,
Weng A, Otterness IG, & Kunkel SL. Biologic and
immunohistochemical analysis of macrophage interleukin- 1 alpha, - 1
beta, and tumor necrosis factor production during the peritoneal
exudative response. J Leukoc Biol 46 (6): 529-37, 1989.
View Abstract