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PUBLICATIONS
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Falconer E, Chavez EA, Henderson A, Poon
SSS, McKinney S, Brown L, Huntsman DG & Lansdorp PM. Identification of sister chromatids
by DNA template strand sequences.
Nature (Epub ahead of print on |
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Calado RT, Regal JA,
Hills M, Yewdell WT, Dalmazzo
LF, Zago MA, Lansdorp
PM, Hogge D, Chanock
SJ, Estey EH, Falcao RP
& Young NS. Constitutional hypomorphic
telomerase mutations in patients with acute myeloid leukemia. Proc Natl Acad Sci |
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Hills M, Lucke K,
Chavez EA, Eaves CJ & Lansdorp PM.
Probing the mitotic history and developmental stage of hematopoietic cells
using single telomere length analysis (STELA). Blood 113: 5765-5775, 2009. |
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Lansdorp PM. Telomeres and
disease. EMBO J 28: 2532-2540, 2009. |
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Calado RT, Regal JA, |
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Savage
SA, Giri N, Baerlocher
GM, Orr N, Lansdorp PM & Alter
BP. TINF2, a component of the Shelterin telomere
protection complex, is mutated in dyskeratosis congenita. Am J Hum Genet 82: 501-509, 2008. |
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Lansdorp PM. Telomeres, stem
cells and hematology. Blood 111:
1759-1766, 2008. |
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Aubert
G & Lansdorp P. Telomeres and
aging. Physiol Rev 82:557-579, 2008. |
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Alder
JK, Chen JJ, Lancaster L, Danoff S, Su SC, Cogan
JD, Vulto I, Xie M, Qi X,
Tuder RM, Phillips JAI, Lansdorp PM, Loyd JE & Armanios MY. Short telomeres are a risk factor for
idiopathic pulmonary fibrosis. Proc Natl Acad Sci
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Lansdorp PM. Immortal strands?
Give me a break. Cell 129: 1244-1247,
2007. |
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Baerlocher GM, Rice K, Vulto
I & Lansdorp PM. Longitudinal
data on telomere length in leukocytes from newborn baboons support a marked
drop in stem cell turnover around one year of age. Aging Cell 6: 121-123, 2007. |
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Armanios MY, Chen JJL,
Cogan JD, Alder JK, Ingersoll RG, Xie M, Markin C, Lawson WE, Vulto I, Phillips JAI, Lansdorp PM, Greider
CW & Loyd JE. Telomerase mutations in families
with idiopathic pulmonary fibrosis. N Engl J Med 356: 1317-1326, 2007. |
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Alter
BP, Baerlocher GM, Savage SA, Chanock
SJ, Weksler BB, Willner
JP, Peters JA, Giri N & Lansdorp PM. Very short telomere length by flow fluorescence in
situ hybridization identifies patients with dyskeratosis
congenita.
Blood 110: 1439-1447, 2007. |
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Baerlocher GM, Vulto I, de Jong G & Lansdorp
PM. Flow cytometry and FISH to measure the
average length of telomeres (flow FISH).
Nat Protoc 1: 2365-2376, 2006. |
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Yamaguchi
H, Calado RT, Ly H, Kajigaya
S, Baerlocher GM, Chanock
SJ, Lansdorp PM & Young NS. Mutations in TERT, the Gene for
Telomerase Reverse Transcriptase, in Aplastic
Anemia. N Engl J Med 352:1413-1424, 2005. |
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Lansdorp
PM.
Major Cutbacks at chromosome ends. Trends Biochem Sci 30:388-395, 2005. |
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Ding H, Schertzer M, Wu X, Gersteinsen
M, Selig S, Kammori M, Pourvali
R, Poon S, Vulto I, Chavez E, Tam PPL, Nagy A & Lansdorp
PM. Regulation of murine telomere length by Rtel: An essential gene encoding a helicase-like
protein. Cell 117:873-886, 2004. |
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Baerlocher
GM, Mak J, Roth A, Rice KS & Lansdorp PM.
Telomere shortening in leukocyte subpopulations from baboons. J Leukoc Biol 73:289-296, 2003. |
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Fogarty PF, Yamaguchi H, Wiestner
A, Baerlocher GM, Sloand
E, Zeng WS, Read EJ, Lansdorp PM & Young
NS. Late presentation of dyskeratosis congenita as apparently acquired aplastic
anaemia due to mutations in telomerase RNA. Lancet
(Research Letter) 362:1628-1630, 2003. |
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Roth A, Yssel H, Pene J, Chavez EA, Schertzer M, Lansdorp PM, Spits
H & Luiten RM. Telomerase levels control the
lifespan of human T lymphocytes. Blood 102:849-857, 2003. |
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Roth A, Vercauteren S,
Sutherland HJ & Lansdorp PM. Telomerase is limiting the growth in
acute myeloid leukemia cells. Leukemia 17:2410-2417, 2003. |
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Cheung I, Schertzer M, Rose A & Lansdorp PM.
Disruption of dog-1 in Caenorhabditis
elegans triggers deletions upstream of
guanine-rich DNA. Nat Genet 31:405-409, 2002. |
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Verfaillie CM,
Pera MF & Lansdorp PM. Stem cells: hype
and reality. In: Hematology 2002,
American Society of Hematology Education Program, The American Society of Hematology,
Washington, DC, pp 369-391, 2002. |
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Brummendorf
TH, Maciejewski JP, Mak
J, Young NS & Lansdorp PM. Telomere length in leukocyte
subpopulations of patients with aplastic anemia.
Blood 97:895-900, 2001. |
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Hande
MP, Balajee AS, Tchirkov
A, Wynshaw-Boris A & Lansdorp PM.
Extra-chromosomal telomeric DNA in cells from Atm-/- mice and patients with
ataxia-telangiectasia. Hum Mol Genet 10:519-528,
2001. |
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Poon SS & Lansdorp PM. Measurements of
telomere length on individual chromosomes by image cytometry.
In: Methods in Cell Biology:
Flow Cytometry, Chapter 33, Vol. 64, Edition 64
(eds. Z Darzynkiewicz, HA Crissman
& JP Robinson), Academic Press, San Diego, CA, pp 69-96, 2001. |
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Rufer
N, Brummendorf TH, Chapuis
B, Helg C, Lansdorp PM & Roosnek E. Accelerated telomere shortening in
hematological lineages is limited to the first year following stem cell
transplantation. Blood 97:575-577, 2001. |
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Brummendorf
TH, Holyoake TL, Rufer N, Barnett MJ, Schulzer M, Eaves CJ, Eaves AC & Lansdorp PM.
Prognostic implications of differences in telomere length between normal and
malignant cells from patients with chronic myeloid leukemia measured by flow cytometry. Blood 95:1883-1890, 2000. |
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Lanza
RP, Cibelli JB, Blackwell C, Cristofalo
VJ, Francis MK, Baerlocher GM, Mak
J, Schertzer M, Chavez EA, Sawyer N, Lansdorp PM & West MD.
Extension of cell life-span and telomere length in animals cloned from
senescent somatic cells. Science 288:665-669, 2000. |
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Liu Y, Snow BE, Hande MP, Yeung D, Erdmann NJ, Wakeham A,
Itie A, Siderovski DP, Lansdorp
PM, Robinson MO & Harrington L. The telomerase reverse transcriptase
is limiting and necessary for telomerase function in vivo. Curr Biol 10:1459-1462, 2000. |
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Martens UM, Chavez
EA, Poon SSS, Schmoor C & Lansdorp PM. Accumulation
of short telomeres in human fibroblasts prior to replicative
senescence. Exp Cell Res 256:291-299, 2000. |
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Hande MP, Samper E, Lansdorp
P & Blasco MA. Telomere length dynamics and
chromosomal instability in cells derived from telomerase null mice. J Cell Biol 144:589-601, 1999. |
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Rufer
N, Brummendorf TH, Kolvraa
S, Bischoff C, Christensen K, Wadsworth L, Schultzer
M & Lansdorp PM. Telomere fluorescence measurements in
granulocytes and T lymphocyte subsets point to a high turnover of
hematopoietic stem cells and memory T cells in early childhood. J Exp Med
190:157-167, 1999. |
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Surralles J, Hande
MP, Marcos R & Lansdorp PM. Accelerated
telomere shortening in the human inactive X chromosome. Am
J Hum Genet 65:1617-1622, 1999. |
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Wan TSK, Martens UM, Poon SSS, Tsao
S-W, Chan LC & Lansdorp PM. Absence or low number of telomere
repeats at junctions of dicentric chromosomes.
Genes Chromosomes Cancer 24:83-86, 1999. |
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Lansdorp PM.
Self-renewal of stem cells. Biol Blood Marrow
Transplant 3:171-178, 1997. |
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Zijlmans
JMJM, Martens UM, Poon SSS, |
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Lansdorp PM, Dragowska W, Mayani H.
Ontogeny-related changes in
proliferative potential of human hematopoietic cells. J Exp Med 178(3):787-91.
(1993). |
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Lansdorp PM, Dragowska W.
Long-term erythropoiesis from constant numbers of CD34+ cells in
serum-free cultures initiated with highly purified progenitor cells from
human bone marrow. J
Exp Med 175(6):1501-9. (1992). |
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Sutherland HJ, Eaves CJ, Eaves AC, Dragowska W, Lansdorp PM. Characterization and partial
purification of human marrow cells capable of initiating long-term hematopoiesis in vitro. Blood 74(5):1563-70. (1989). |
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van den Engh G, Trask B, Lansdorp P, Gray J.
Improved resolution of flow cytometric measurements of Hoechst- and
chromomycin-A3-stained human chromosomes after addition of citrate and
sulfite. Cytometry 9(3):266-70. (1988). |
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Lansdorp PM, Aalberse RC, Bos R, Schutter WG, Van Bruggen EF. Cyclic
tetramolecular complexes of monoclonal antibodies:
a new type of cross-linking reagent. Eur J Immunol
16(6):679-83. (1986). |
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