Selected Publications 

     Kennah E, Ringrose A, Zhou LL, Esmailzadeh S, Qian H, Su MW, Zhou Y, Jiang X.  Identification of tyrosine kinase, HCK, and
 tumor suppressor, BIN1, as potential mediators of AHI-1 oncogene in primary and transformed CTCL cells.  Blood 113 (19): 4646-55,  2009.  View Abstract

      Forrest DL, Jiang X, Eaves CJ & Smith CL. An approach to the management of chronic myeloid leukemia in British Columbia. 
 Curr Oncol 15: 48-55, 2008.  View Article

      Jiang X, Zhao Y, Forrest D, Smith C, Eaves A and Eaves C.  Stem Cell Biomarkers in Chronic Myeloid Leukemia.  Disease Markers
      24:201-216, 2008.  View Abstract

      Sheng G, Xu X, Lin Y-F, Wang C-E, Rong J, Cheng D, Peng J, Jiang X, Li S-H & Li X-J. Huntingtin-associated protein 1 interacts
      with Ahi1 to regulate cerebellar and brainstem development in mice. J Clin Invest 118: 2785-2795, 2008.  View Article
       
      Zhou LL, Zhao Y, Ringrose A, DeGeer D, Kennah E, Lin AEJ, Sheng G, Li X-J, Turhan A & Jiang X. AH1-1 interacts with BCR-ABL
      and modulates BCR-ABL transforming activity and imatinib response of CML stem/progenitor cells.  J Exp Med 205: 2657-2671, 
      2008.  View Article

.        Jiang X, Saw KM, Eaves A, & Eaves C. Instability of BCR-ABL gene in primary and cultured chronic myeloid leukemia stem cells.
  J  Natl Cancer Inst 99 (9): 680-93, 2007. View Abstract

.        Jiang X, Smith C, Eaves A, & Eaves C. The challenges of targeting chronic myeloid leukemia stem cells. Clin Lymphoma Myeloma 7
  Suppl 2: S71-80, 2007.  View Abstract

.        Jiang X, Zhao Y, Smith C, Gasparetto M, Turhan A, Eaves A, & Eaves C. Chronic myeloid leukemia stem cells possess multiple
 unique features of resistance to BCR-ABL targeted therapies. Leukemia 21 (5): 926-35, 2007.  View Abstract

      Jorgensen HG, Copland M, Allan EK, Jiang X, Eaves A, Eaves C, & Holyoake TL. Intermittent exposure of  primitive quiescent

      chronic myeloid leukemia cells to granulocyte-colony stimulating factor in vitro promotes their elimination by imatinib mesylate. Clin    

      Cancer Res 12 (2): 626-33, 2006. View Article

      Ringrose A, Zhou Y, Pang E, Zhou L, Lin AE, Sheng G, Li XJ, Weng A, Su MW, Pittelkow MR, & Jiang X. Evidence for an oncogenic 

      role of AHI-1 in Sezary syndrome, a leukemic variant of human cutaneous T-cell lymphomas. Leukemia 20 (9): 1593-601, 2006.

      View Article

     Zeng F, Chen MJ, Baldwin DA, Gong ZJ, Yan JB, Qian H, Wang J, Jiang X, Ren ZR, Sun D, & Huang SZ. Multiorgan engraftment      and differentiation of human cord blood CD34+ Lin- cells in goats assessed by gene expression profiling. Proc Natl Acad Sci USA 103
(20): 7801-6, 2006.  View Article

           Chalandon Y, Jiang X, Christ O, Loutet S, Thanopoulou E, Eaves A, & Eaves C. BCR-ABL-transduced human cord blood cells
 produce abnormal populations in immunodeficient mice. Leukemia 19 (3): 442-8, 2005. View Article

      Eisterer W, Jiang X, Christ O, Glimm H, Lee KH, Pang E, Lambie K, Shaw G, Holyoake TL, Petzer AL, Auewarakul C, Barnett MJ,
 Eaves CJ, & Eaves AC. Different subsets of primary chronic myeloid leukemia stem cells engraft immunodeficient mice and produce a
 model of the human disease. Leukemia 19 (3): 435-41, 2005.  View Article

     Chalandon Y, Jiang X, Loutet S, Eaves AC, & Eaves CJ. Growth autonomy and lineage switching in BCR-ABL-transduced human cord
 blood cells depend on different functional domains of BCR-ABL. Leukemia 18 (5): 1006-12, 2004.  View Abstract

      Jiang X, Zhao Y, Chan WY, Vercauteren S, Pang E, Kennedy S, Nicolini F, Eaves A, & Eaves C. Deregulated expression in Ph+
 human leukemias of AHI-1, a gene activated by insertional mutagenesis in mouse models of leukemia. Blood 103 (10): 3897-904,
 2004.  View Abstract

       Eaves C, Jiang X, Eisterer W, Chalandon Y, Porada G, Zanjani E, & Eaves A. New models to investigate mechanisms of disease
  genesis from primitive BCR-ABL(+) hematopoietic cells. Ann N Y Acad Sci 996: 1-9, 2003. View Abstract

       Jiang X, Stuible M, Chalandon Y, Li A, Chan WY, Eisterer W, Krystal G, Eaves A, & Eaves C. Evidence for a positive role of SHIP in
  the BCR-ABL-mediated transformation of primitive murine hematopoietic cells and in human chronic myeloid leukemia. Blood 102 (8):
  2976-84, 2003. View Abstract

      Jorgensen HG, Allan EK, Jiang X, Liakopoulou E, Richmond L, Eaves CJ, Eaves AC, & Holyoake TL. Stage-specific alterations in  

      serum levels of G-CSF in chronic myeloid leukaemia. Leukemia 17 (7): 1430-2, 2003. View Abstract

     Chalandon Y, Jiang X, Hazlewood G, Loutet S, Conneally E, Eaves A, & Eaves C. Modulation of p210(BCR-ABL) activity in   transduced primary human hematopoietic cells controls lineage programming. Blood 99 (9): 3197-204, 2002.  View Abstract

      Eisterer W, Jiang X, Bachelot T, Pawliuk R, Abramovich C, Leboulch P, Hogge D, & Eaves C. Unfulfilled promise of endostatin in a
 gene therapy-xenotransplant model of human acute lymphocytic leukemia. Mol Ther 5 (4): 352-9, 2002.  View Abstract

      Holyoake TL, Jiang X, Drummond MW, Eaves AC, & Eaves CJ. Elucidating critical mechanisms of deregulated stem cell turnover in
 the chronic phase of chronic myeloid leukemia. Leukemia 16 (4): 549-58, 2002.  View Abstract

      Jiang X, Ng E, Yip C, Eisterer W, Chalandon Y, Stuible M, Eaves A, & Eaves CJ. Primitive interleukin 3 null hematopoietic cells
 transduced with BCR-ABL show accelerated loss after culture of factor-independence in vitro and leukemogenic activity in vivo. Blood    100 (10): 3731-40, 2002.  View Abstract

      Jiang X, Hanna Z, Kaouass M, Girard L, & Jolicoeur P. Ahi-1, a novel gene encoding a modular protein with WD40-repeat and SH3
 domains, is targeted by the Ahi-1 and Mis-2 provirus integrations. J Virol 76 (18): 9046-59, 2002.   View Abstract

      Holyoake TL, Jiang X, Jorgensen HG, Graham S, Alcorn MJ, Laird C, Eaves AC, & Eaves CJ. Primitive quiescent leukemic cells       from patients with chronic myeloid leukemia spontaneously initiate factor-independent growth in vitro in association with up-regulation of
 expression of interleukin-3. Blood 97 (3): 720-8, 2001.  View Abstract

      Jiang X, Fujisaki T, Nicolini F, Berger M, Holyoake T, Eisterer W, Eaves C, & Eaves A. Autonomous multi-lineage differentiation in 
 vitro of primitive CD34+ cells from patients with chronic myeloid leukemia. Leukemia 14 (6): 1112-21, 2000.  View Abstract

      Holyoake T, Jiang X, Eaves C, & Eaves A. Isolation of a highly quiescent subpopulation of primitive leukemic cells in chronic myeloid
 leukemia. Blood 94 (6): 2056-64, 1999.  View Abstract

      Jiang X, Lopez A, Holyoake T, Eaves A, & Eaves C. Autocrine production and action of IL-3 and granulocyte colony-stimulating factor
 in chronic myeloid leukemia. Proc Natl Acad Sci U S A 96 (22): 12804-9, 1999.  View Abstract